ZIF-8 as a promising drug delivery system for benznidazole: development, characterization, in vitro dialysis release and cytotoxicity

Chagas disease (CD), caused by the flagellate protozoan Trypanosoma cruzi , is one of the major public health problems in developing countries. Benznidazole (BNZ) is the only drug available for CD treatment in most countries, however, it presents high toxicity and low bioavailability. To address the...

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Bibliographic Details
Published in:	Scientific reports Vol. 10; no. 1; p. 16815
Main Authors:	de Moura Ferraz, Leslie Raphael, Tabosa, Alinne Élida Gonçalves Alves, da Silva Nascimento, Débora Dolores Souza, Ferreira, Aline Silva, de Albuquerque Wanderley Sales, Victor, Silva, José Yago Rodrigues, Júnior, Severino Alves, Rolim, Larissa Araújo, de Souza Pereira, Jorge José, Rolim-Neto, Pedro José
Format:	Journal Article
Language:	English
Published:	London Nature Publishing Group UK 08-10-2020
Subjects:	631/154/152 639/301/357/404 639/925/930/1032 639/925/930/12 692/308/153 692/699/255 692/699/255/1715 Dialysis Drug Carriers Humanities and Social Sciences Humans Hydrogen-Ion Concentration Imidazoles multidisciplinary Nitroimidazoles - administration & dosage Nitroimidazoles - adverse effects Nitroimidazoles - pharmacokinetics Science Science (multidisciplinary) Spectrometry, X-Ray Emission Spectroscopy, Fourier Transform Infrared Trypanocidal Agents - administration & dosage Trypanocidal Agents - adverse effects Trypanocidal Agents - pharmacokinetics Zeolites
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