Comparison of cumulative and single bolus dose techniques for determining the potency of vecuronium

The potency of vecuronium was determined using single bolus dose administrations of 10-50 micrograms kg-1 in 28 patients anaesthetized with thiopentone, nitrous oxide, oxygen and fentanyl. The results were compared with those previously obtained using a cumulative dose technique in a comparable grou...

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Bibliographic Details
Published in:	British journal of anaesthesia : BJA Vol. 57; no. 11; p. 1060
Main Authors:	Gibson, F M, Mirakhur, R K, Clarke, R S, Lavery, G G
Format:	Journal Article
Language:	English
Published:	England 01-11-1985
Subjects:	Adult Dose-Response Relationship, Drug Humans Injections, Intravenous Neuromuscular Blocking Agents - administration & dosage Neuromuscular Blocking Agents - pharmacology Pancuronium - administration & dosage Pancuronium - analogs & derivatives Pancuronium - pharmacology Therapeutic Equivalency Vecuronium Bromide
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Summary:	The potency of vecuronium was determined using single bolus dose administrations of 10-50 micrograms kg-1 in 28 patients anaesthetized with thiopentone, nitrous oxide, oxygen and fentanyl. The results were compared with those previously obtained using a cumulative dose technique in a comparable group of 10 patients. The 50% and 95% blocking doses (ED50 and ED95) of vecuronium were found to be 23.1 and 39.6 micrograms kg-1, respectively. These were significantly lower than the 30.5 and 56.7 micrograms kg-1 obtained previously using the cumulative dose technique. We recommend the use of single bolus dose method of determining potency for relatively shorter-acting drugs like vecuronium.
ISSN:	0007-0912
DOI:	10.1093/bja/57.11.1060