Quantum-Dot-Based Molecular Ruler for Multiplexed Optical Analysis

Quantum-Dot-Based Molecular Ruler for Multiplexed Optical Analysis

Nanoshapes and sizes: A time‐resolved multicolor optical analysis of Förster resonance energy transfer (FRET) from a luminescent terbium complex to different semiconductor quantum dots allows the rapid and accurate measurement of the size and shape of different functionalized quantum dots under phys...

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Bibliographic Details
Published in:Angewandte Chemie (International ed.) Vol. 49; no. 41; pp. 7570 - 7574
Main Authors: Morgner, Frank, Geißler, Daniel, Stufler, Stefan, Butlin, Nathaniel G, Löhmannsröben, Hans-Gerd, Hildebrandt, Niko
Format: Journal Article
Language:English
Published: Weinheim Wiley-VCH Verlag 04-10-2010
WILEY-VCH Verlag
WILEY‐VCH Verlag
Subjects:
Biosensing Techniques
biosensors
Fluorescence Resonance Energy Transfer - methods
FRET
Luminescent Agents - chemistry
Particle Size
Quantum Dots
spectroscopic rulers
terbium
Terbium - chemistry
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Summary:Nanoshapes and sizes: A time‐resolved multicolor optical analysis of Förster resonance energy transfer (FRET) from a luminescent terbium complex to different semiconductor quantum dots allows the rapid and accurate measurement of the size and shape of different functionalized quantum dots under physiological conditions. This spectroscopic ruler opens the possibility of a simultaneous analysis of different biological processes at sub‐nanomolar concentrations.
Bibliography:http://dx.doi.org/10.1002/anie.201002943
European Commission - No. NANOGNOSTICS-HEALTH-F5-2009-242264; No. Life-LSHB-CT-2007-037933
We would like to thank the European Commission for financial support (FP7 Collaborative Project NANOGNOSTICS-HEALTH-F5-2009-242264 and FP6 Specific Targeted Research Project POC4 Life-LSHB-CT-2007-037933) and Dr. Loïc J. Charbonnière for a fruitful discussion about the manuscript.
ArticleID:ANIE201002943
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We would like to thank the European Commission for financial support (FP7 Collaborative Project NANOGNOSTICS‐HEALTH‐F5‐2009‐242264 and FP6 Specific Targeted Research Project POC4 Life‐LSHB‐CT‐2007‐037933) and Dr. Loïc J. Charbonnière for a fruitful discussion about the manuscript.
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ISSN:1433-7851
1521-3773
DOI:10.1002/anie.201002943