Aquaporin 9 is down-regulated in hepatocellular carcinoma and its over-expression suppresses hepatoma cell invasion through inhibiting epithelial-to-mesenchymal transition

Highlights • AQP9 is down-regulated in hepatocellular carcinoma tissues and cell lines • AQP9 over-expression inhibits liver cancer cell migration and invasion • AQP9 over-expression inhibits xenograft liver tumor growth and lung metastasis • AQP9 over-expression inhibits epithelial-to-mesenchymal t...

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Bibliographic Details
Published in:	Cancer letters Vol. 378; no. 2; pp. 111 - 119
Main Authors:	Zhang, Wen-guang, Li, Chuan-fei, Liu, Min, Chen, Xiao-feng, Shuai, Kai, Kong, Xing, Lv, Lin, Mei, Zhe-chuan
Format:	Journal Article
Language:	English
Published:	Ireland Elsevier Ireland Ltd 10-08-2016 Elsevier Limited
Subjects:	Adult Animals Aquaporin 9 Aquaporins Aquaporins - genetics Aquaporins - metabolism Carcinoma, Hepatocellular - genetics Carcinoma, Hepatocellular - metabolism Carcinoma, Hepatocellular - secondary Cell adhesion & migration Cell growth Cell Movement Epithelial-Mesenchymal Transition Epithelial-to-mesenchymal transition Female Flow cytometry Gene Expression Regulation, Neoplastic Hematology, Oncology and Palliative Medicine Hep G2 Cells Hepatocellular carcinoma Humans Invasion Liver cancer Liver Neoplasms - genetics Liver Neoplasms - metabolism Liver Neoplasms - pathology Lung Neoplasms - genetics Lung Neoplasms - metabolism Lung Neoplasms - prevention & control Lung Neoplasms - secondary Male Metastasis Mice, Nude Middle Aged Neoplasm Invasiveness Phosphatidylinositol 3-Kinase - metabolism Phosphorylation PI3K/AKT Proteins Proto-Oncogene Proteins c-akt - metabolism RNA Interference Signal Transduction Studies Time Factors Transfection Tumor Burden Tumors China aquaporin 9 invasion PI3K/AK hepatocellular carcinoma epithelial-to-mesenchymal transition Hepatocellular carcinoma Aquaporin 9 Epithelial-to-mesenchymal transition Invasion PI3K/AKT
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Summary:	Highlights • AQP9 is down-regulated in hepatocellular carcinoma tissues and cell lines • AQP9 over-expression inhibits liver cancer cell migration and invasion • AQP9 over-expression inhibits xenograft liver tumor growth and lung metastasis • AQP9 over-expression inhibits epithelial-to-mesenchymal transition • AQP9 over-expression decreases expression of PI3K and p-Akt
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	0304-3835 1872-7980
DOI:	10.1016/j.canlet.2016.05.021