Population-based trends in outcomes in adenoid cystic carcinoma of the oral cavity

• Published in: American journal of otolaryngology Vol. 37; no. 5; pp. 398 - 406
• Main Authors: Dubal, Pariket M., DO, Unsal, Aykut A., DO, Chung, Sei Y., BS, Patel, Akshay V., DO, Park, Richard Chan Woo, MD, FACS, Baredes, Soly, MD, FACS, Eloy, Jean Anderson, MD, FACS
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01-09-2016; Elsevier Limited
• Subjects: Adolescent; Adult; Age; Aged; Aged, 80 and over; Carcinoma, Adenoid Cystic - epidemiology; Carcinoma, Adenoid Cystic - pathology; Confidence intervals; Disease-Free Survival; Female; Gender; Humans; Incidence; Male; Medical prognosis; Metastasis; Middle Aged; Mouth; Mouth Neoplasms - epidemiology; Mouth Neoplasms - pathology; Neck; Neoplasm Grading; Otolaryngology; Population; Radiation therapy; Retrospective Studies; SEER Program; Software; Surgery; Survival Rate; Trends; Tumors; United States - epidemiology; Young Adult
• ISSN: 0196-0709; 1532-818X
• DOI: 10.1016/j.amjoto.2016.06.001

Abstract Purpose Adenoid cystic carcinoma (ACC) is a rare malignant epithelial neoplasm of secretory glands of the upper aerodigestive tract. It accounts for 3–5% of head and neck malignancies and most commonly arises from the minor salivary glands of the oral cavity. The clinical behavior of ACC from specific anatomic subsites, including the oral cavity, is not well described in the literature. We aim to elucidate patient demographics, clinicopathologic features, incidence, and survival trends for oral cavity ACC (OCACC). Methods Retrospective population-based analysis of OCACC in the SEER database between 1973 and 2012. Results 1066 OCACC patients were identified, of which 57.7% were female (P < 0.0001). Incidence was 0.049 per 100,000. Whites were most commonly affected (81.1%). The hard palate was the most commonly involved subsite (44.1%). Nodal involvement was seen in 8.4% of cases and distant metastasis was present in 6.2% of cases at the time of presentation. Disease-specific survival (DSS) rates at 1, 5, 10, 15, and 20 years were 97.4%, 83.9%, 69.9%, 57.6%, and 46.2%, respectively. Females had a higher 5-year DSS (87.8%) than males (78.4%, P = 0.0004). Cases treated with surgery had a favorable prognosis regardless of whether they received radiotherapy (P < 0.0001). Nodal involvement reduced 5-year DSS by 51.6% (P < 0.0001), while distant metastasis reduced 5-year DSS by 46.4% (P < 0.0001). Conclusions OCACC is a rare malignancy with females and whites being more commonly affected. At presentation, regional and distant metastases are uncommon. Poor prognostic indicators include male gender, nonsurgical therapy, nodal involvement, and distant metastasis.