Spontaneous regression of CIN and delayed-type hypersensitivity to HPV-16 oncoprotein E7

We investigated delayed-type hypersensitivity to human papillomavirus (HPV) in women with cervical dysplasia or cancer. Women were challenged by skin tests with synthetic HPV-16 E7 oncoprotein peptides. 11 women were regressors (cleared disease without treatment) and 37 were progressors (required su...

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Bibliographic Details
Published in:	The Lancet (British edition) Vol. 356; no. 9246; pp. 1985 - 1986
Main Authors:	Höpfl, Reinhard, Heim, Kurt, Christensen, Neil, Zumbach, Klaus, Wieland, Ulrike, Volgger, Birgit, Widschwendter, Andreas, Haimbuchner, Sandra, Müller-Holzner, Elisabeth, Pawlita, Michael, Pfister, Herbert, Fritsch, Peter
Format:	Journal Article
Language:	English
Published:	London Elsevier Ltd 09-12-2000 Lancet Elsevier Limited
Subjects:	Biological and medical sciences Cervical Intraepithelial Neoplasia - immunology Cervical Intraepithelial Neoplasia - virology Female Genital system. Mammary gland Humans Hypersensitivity Hypersensitivity, Delayed - immunology Hypersensitivity, Delayed - virology Investigative techniques, diagnostic techniques (general aspects) Male Medical research Medical sciences Oncogene Proteins, Viral - immunology Papillomaviridae - immunology Papillomavirus E7 Proteins Papillomavirus Infections - immunology Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques Peptides Proteins Remission, Spontaneous Sexually transmitted diseases Skin Skin Tests STD Tumor Virus Infections - immunology Viruses Women Human T cell receptor Cytologic investigation Helper cell Delayed hypersensitivity Tumoral marker Papovaviridae Carcinogenesis Female genital diseases Infection Papillomavirus Virus Human papillomavirus 16 Human papillomavirus Cervical dysplasia Viral disease Uterine diseases Female Comparative study Skin test
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