VHL Expression in Kidney Cancer: Relation to Metastasis Development, Transcription and Growth Factors and Component of Akt/m-TOR Signaling Pathway

• Published in: Bulletin of experimental biology and medicine Vol. 167; no. 5; pp. 671 - 675
• Main Authors: Spirina, L. V., Kondakova, I. V., Yurmazov, Z. A., Usynin, E. A., Slonimskaya, E. M., Lushnikova, N. A., Podnebesnova, D. V.
• Format: Journal Article
• Language: English
• Published: New York Springer US 01-09-2019; Springer
• Subjects: Basic Helix-Loop-Helix Transcription Factors - genetics; Basic Helix-Loop-Helix Transcription Factors - metabolism; Biomedical and Life Sciences; Biomedicine; Carbonic Anhydrase IX - genetics; Carbonic Anhydrase IX - metabolism; Carcinoma, Renal Cell - genetics; Carcinoma, Renal Cell - metabolism; Carcinoma, Renal Cell - pathology; Carcinoma, Renal Cell - surgery; Cell Biology; Development and progression; Gene Expression Profiling; Gene Expression Regulation, Neoplastic; Genetic transcription; Humans; Hypoxia-Inducible Factor 1, alpha Subunit - genetics; Hypoxia-Inducible Factor 1, alpha Subunit - metabolism; Internal Medicine; Kidney cancer; Kidney Neoplasms - genetics; Kidney Neoplasms - metabolism; Kidney Neoplasms - pathology; Kidney Neoplasms - surgery; Laboratory Medicine; Lymphatic Metastasis; Metastasis; Neoplasm Staging; Oncology; Pathology; Pazopanib; Proto-Oncogene Proteins c-akt - genetics; Proto-Oncogene Proteins c-akt - metabolism; RNA; Signal Transduction; TOR Serine-Threonine Kinases - genetics; TOR Serine-Threonine Kinases - metabolism; Transcription Factor RelA - genetics; Transcription Factor RelA - metabolism; Vascular Endothelial Growth Factor A - genetics; Vascular Endothelial Growth Factor A - metabolism; Vascular Endothelial Growth Factor Receptor-2 - genetics; Vascular Endothelial Growth Factor Receptor-2 - metabolism; Von Hippel-Lindau Tumor Suppressor Protein - genetics; Von Hippel-Lindau Tumor Suppressor Protein - metabolism; kidney cancer; nuclear factors; VHL; growth factors; components of Akt/m-TOR signaling pathway
• ISSN: 0007-4888; 1573-8221
• DOI: 10.1007/s10517-019-04596-9

Von Hippel—Lindau protein (VHL) is associated with the development and progression of kidney cancer. An increase in VHL expression was found in patients with the disseminated form of the disease compared to the localized cancer, which was combined with a uniform distribution of decreased (<1.0) and increased (>1.0) VHL mRNA levels in renal cancer patients depending on the dissemination of the process. The increase in VHL expression was accompanied an increase in the level of mRNA for NF-κB p65 and kinases PDK1 and Akt. The revealed data indicate the importance of molecular biological parameters in oncogenesis.