Cannabinoids lead to enhanced virulence of the smallpox vaccine (vaccinia) virus

Abstract Indian hemp is used since thousands of years as herbal drug. We found that a single dose of cannabis resin was equally active as Δ9-tetrahydrocannabinol (THC) enhancing severity and duration of symptoms in vaccinia virus infected mice. Cowpox virus did not cause symptomatic disease, but som...

Full description

Saved in:

Bibliographic Details
Published in:	Immunobiology (1979) Vol. 216; no. 6; pp. 670 - 677
Main Authors:	Huemer, Hartwig P, Lassnig, Caroline, Bernhard, David, Sturm, Sonja, Nowotny, Norbert, Kitchen, Maria, Pavlic, Marion
Format:	Journal Article
Language:	English
Published:	Netherlands Elsevier GmbH 01-06-2011
Subjects:	Advanced Basic Science Allergy and Immunology Animals Antibody Antibody Formation - drug effects Apoptosis - drug effects Cannabidiol Cannabinoids - pharmacology Cannabinol Cannabis Cell Line Cell Proliferation - drug effects Cowpox virus Cowpox virus - drug effects Cowpox virus - immunology Cytokines - biosynthesis Dronabinol - pharmacology Female Humans Immunosuppression Leukocytes, Mononuclear - drug effects Lymphocyte Mice Mice, Inbred BALB C Mitogen Mitogens - antagonists & inhibitors Poxvirus Rabbits Receptors, Antigen, T-Cell - immunology Receptors, Antigen, T-Cell - metabolism Spleen - drug effects Spleen - metabolism T-Lymphocytes - drug effects T-Lymphocytes - immunology Tetrahydrocannabinol Vaccinia - immunology Vaccinia - physiopathology Vaccinia virus Vaccinia virus - drug effects Vaccinia virus - pathogenicity Virulence cowpox virus CBD DMSO dimethylsulfoxide PHA EtOH lipopolysaccharide (from E. coli) vaccinia virus FACS ethanol without THC CBN LPS w/o Tetrahydrocannabinol HPLC peripheral blood mononuclear cells Cann cannabinol GC–MS Antibody PWM cannabis fluorescence avtivated cell sorting PBMC cannabidiol high performance liquid chromatography Immunosuppression pokeweed mitogen CPXV VACV gas chromatography–mass spectrometry Δ9-tetrahydrocannabinol phytohemagglutinine SEM Mitogen standard error of the mean Lymphocyte Cannabidiol Cannabinol Cannabis Vaccinia virus Cowpox virus
Online Access:	Get full text
Tags:	Add Tag No Tags, Be the first to tag this record!

Be the first to leave a comment!