Diclofenac induces apoptosis in hepatocytes by alteration of mitochondrial function and generation of ROS

Diclofenac is a non-steroidal anti-inflammatory drug that is widely used clinically but side effects associated with the administration of the drug have been reported. The apoptotic effect of the drug has been evaluated in human and rat hepatocytes. Apoptosis was observed after exposure to sub-cytot...

Full description

Saved in:

Bibliographic Details
Published in:	Biochemical pharmacology Vol. 66; no. 11; pp. 2155 - 2167
Main Authors:	Gómez-Lechón, M.José, Ponsoda, Xavier, O’Connor, Enrique, Donato, Teresa, Castell, José V., Jover, Ramiro
Format:	Journal Article
Language:	English
Published:	New York, NY Elsevier Inc 01-12-2003 Elsevier Science
Subjects:	Animals Apoptosis - drug effects Apoptosis - physiology BclX L Bid Biological and medical sciences Caspases 3, 8 and 9 Diclofenac Diclofenac - pharmacology DNA fragmentation Hepatocytes - cytology Hepatocytes - drug effects Hepatocytes - metabolism Male Medical sciences Mitochondria, Liver - drug effects Mitochondria, Liver - metabolism Mitochondria, Liver - physiology MPT Pharmacology. Drug treatments Rats Rats, Sprague-Dawley Reactive oxygen species Reactive Oxygen Species - metabolism DUBQ Caspases 3, 8 and 9 Reactive oxygen species DMSO SOD DMTU Diclofenac MPT Cs A DCFH-DA LDH MNTC ROS DNA fragmentation BclX L Bid Prostaglandin-endoperoxide synthase Digestive system Enzyme Toxicity Liver Enzyme inhibitor Caspase Pharmacology Non steroidal antiinflammatory agent Peptidases Mitochondria Arylacetic acid derivatives Analgesic BclXL; Caspases 3 Hepatocyte Cell death Antipyretic Hydrolases Oxidoreductases Apoptosis 8 and 9; Bid; Diclofenac; DNA fragmentation; MPT; Reactive oxygen species
Online Access:	Get full text
Tags:	Add Tag No Tags, Be the first to tag this record!

Be the first to leave a comment!