Bitter ginger (Zingiber zerumbet) for patients with solid tumors with no treatment options: A pilot clinical study

• Published in: Complementary therapies in medicine Vol. 80; p. 103021
• Main Authors: de Queiroz, Larissa Vieira, Neto, José Favoreto, Fonseca, Fernando Luiz Affonso, Pinheiro, Carlos Cleomir, del Giglio, Auro
• Format: Journal Article
• Language: English
• Published: Scotland Elsevier Ltd 01-03-2024; Elsevier Limited; Elsevier
• Subjects: Access control; Analgesics; Anxiety; Biocompatibility; Bitter taste; Cancer; Chromatography; Chronic illnesses; Drug dosages; Ginger; Glycoproteins; Health services; Hospitals; Inflammation; Liver diseases; Mental depression; Oils & fats; Oxidation; Palliative care; Patients; Population studies; Quality of life; Questionnaires; Sleep; Solid tumors; Toxicity; Tumors; Zerumbone; Zingiber zerumbet; Brazil; Zingiber zerumbet; Palliative care; Zerumbone
• ISSN: 0965-2299; 1873-6963
• DOI: 10.1016/j.ctim.2024.103021

Zerumbone is a natural compound found in bitter ginger plants (Zingiber zerumbet) that shows antiproliferative, antioxidant, anti-inflammatory, and analgesic properties. We aimed to investigate the role of zerumbone in improving the quality of life and symptom control in cancer patients with no treatment options.
We conducted a pilot, non-randomized, single-center, open prospective, and systematic study on the use of 400 mg of zerumbone twice a day.
The study included 35 patients (mean age, 68 years; 64% men), of which 16 completed the eight-week study. The intention-to-treat population showed no significant changes in weight or sleep quality over the eight-week study. Assessments performed using the European Organisation for Research and Treatment of Cancer Quality of Life Questionnaire Core 30 (EORTC QLQ-C30) showed significant improvements in the quality of life in the global (p = 0.072), activity (p = 0.0393), social (p = 0.0001), and emotional (p = 0.0023) dimensions. The Hospital Anxiety and Depression Scale (HADS) questionnaire scores showed significant improvement in anxiety (p = 0.032) and depression (p = 0.021), while the Functional Assessment of Chronic Illness Therapy-Fatigue (FACIT-F) questionnaire scores also indicated a significant improvement (p = 0.001). Bitter ginger showed low toxicity.
Bitter ginger showed promising results in improving the quality of life and reducing symptoms of anxiety and depression in the study population. A randomized placebo-controlled study is necessary to confirm these results.
This trial was registered under the number FMABC: CAAE – 93459418.00000082, at ISRCTN (BIOMED CENTRAL) NUMBER 4388 (03/07/23) and at Plataforma Brasil (https://plataformabrasil.saude.gov.br/login.jsf)
•Patients with advanced cancer experience symptoms that decrease their quality of life.•We tested Zingiber zerumbet in 35 patients with terminal cancer at a dose of 400 mg PO BID.•We observed significant improvement in their overall quality of life, fatigue, depression and anxiety.•Zingiber zerumbet showed a very tolerable toxicity profile.•A randomized placebo-controlled trial is necessary to confirm our preliminary data.