Randomized Phase II Trial of the Efficacy and Safety of Trastuzumab Combined With Docetaxel in Patients With Human Epidermal Growth Factor Receptor 2–Positive Metastatic Breast Cancer Administered As First-Line Treatment: The M77001 Study Group

This randomized, multicenter trial compared first-line trastuzumab plus docetaxel versus docetaxel alone in patients with human epidermal growth factor receptor 2 (HER2) -positive metastatic breast cancer (MBC). Patients were randomly assigned to six cycles of docetaxel 100 mg/m2 every 3 weeks, with...

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Bibliographic Details
Published in:	Journal of clinical oncology Vol. 23; no. 19; pp. 4265 - 4274
Main Authors:	MARTY, Michel, COGNETTI, Francesco, KENNEDY, John, O'BYRNE, Kenneth, CONTE, Pier Franco, GREEN, Michael, WARD, Carol, MAYNE, Karen, EXTRA, Jean-Marc, MARANINCHI, Dominique, SNYDER, Ray, MAURIAC, Louis, TUBIANA-HULIN, Michèle, CHAN, Stephen, GRIMES, David, ANTON, Antonio, LLUCH, Ana
Format:	Journal Article
Language:	English
Published:	Baltimore, MD American Society of Clinical Oncology 01-07-2005 Lippincott Williams & Wilkins
Subjects:	Adolescent Adult Aged Antibodies, Monoclonal - administration & dosage Antibodies, Monoclonal - adverse effects Antibodies, Monoclonal, Humanized Antineoplastic Combined Chemotherapy Protocols - adverse effects Antineoplastic Combined Chemotherapy Protocols - therapeutic use Biological and medical sciences Breast Neoplasms - drug therapy Breast Neoplasms - metabolism Drug Evaluation Female Humans Leukopenia - chemically induced Medical sciences Middle Aged Neoplasm Metastasis Neutropenia - chemically induced Receptor, ErbB-2 - metabolism Taxoids - administration & dosage Taxoids - adverse effects Trastuzumab Tumors Antineoplastic agent Human Toxicity Treatment efficiency Docetaxel Breast cancer Monoclonal antibody Metastasis Malignant tumor Human Epidermal growth factor Receptor 2 First line treatment Mammary gland diseases Cancerology Taxane derivatives Anticytokine Phase II trial Clinical trial Advanced stage Antimitotic Trastuzumab
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