Hepatitis B virus splicing is enhanced prior to development of hepatocellular carcinoma

Background & Aims The hepatitis B virus (HBV) genome encodes specific sequence elements which promote splicing of viral DNA. It has been previously suggested that spliced HBV (spHBV) variants promote viral replication and protein production, leading to hepatocellular carcinoma (HCC). In this stu...

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Bibliographic Details
Published in:	Journal of hepatology Vol. 59; no. 5; pp. 1022 - 1028
Main Authors:	Bayliss, Julianne, Lim, Lucy, Thompson, Alexander J.V, Desmond, Paul, Angus, Peter, Locarnini, Stephen, Revill, Peter A
Format:	Journal Article
Language:	English
Published:	Netherlands Elsevier B.V 01-11-2013
Subjects:	Adult Carcinoma, Hepatocellular - epidemiology Case-Control Studies Chronic infection DNA, Viral - genetics Female Follow-Up Studies Gastroenterology and Hepatology Genotype Hepatitis B virus (HBV) Hepatitis B virus - genetics Hepatitis B virus - physiology Hepatitis B, Chronic - complications Hepatitis B, Chronic - virology Hepatocellular carcinoma (HCC) Humans Liver Neoplasms - epidemiology Liver transplantation Longitudinal Studies Male Real-time PCR Real-Time Polymerase Chain Reaction Regression Analysis Risk Factors Time Factors Viral Load - genetics Viral Load - physiology Viral splicing Virus Replication - physiology Viral splicing Chronic infection Real-time PCR Hepatitis B virus (HBV) Hepatocellular carcinoma (HCC) Liver transplantation
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