Unravelling the Dermatological Potential of the Brown Seaweed Carpomitra costata

The ever-increasing interest in keeping a young appearance and healthy skin has leveraged the skincare industry. This, coupled together with the increased concern regarding the safety of synthetic products, has boosted the demand for new and safer natural ingredients. Accordingly, the aim of this st...

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Published in:	Marine drugs Vol. 19; no. 3; p. 135
Main Authors:	Susano, Patrícia, Silva, Joana, Alves, Celso, Martins, Alice, Gaspar, Helena, Pinteus, Susete, Mouga, Teresa, Goettert, Márcia Ines, Petrovski, Željko, Branco, Luís B, Pedrosa, Rui
Format:	Journal Article
Language:	English
Published:	Switzerland MDPI 28-02-2021 MDPI AG
Subjects:	3T3 Cells algae Animals anti-enzymatic anti-inflammatory Anti-Inflammatory Agents - isolation & purification Anti-Inflammatory Agents - pharmacology antimicrobial antioxidant Antioxidants - isolation & purification Antioxidants - pharmacology Dermatologic Agents - isolation & purification Dermatologic Agents - pharmacology Free Radical Scavengers - isolation & purification Free Radical Scavengers - pharmacology Inhibitory Concentration 50 marine natural products Mice Phaeophyceae - chemistry Phenols - isolation & purification Phenols - pharmacology RAW 264.7 Cells Reactive Oxygen Species - metabolism antimicrobial antioxidant skincare anti-inflammatory phenolic compounds photoprotective algae anti-enzymatic marine natural products
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Abstract	The ever-increasing interest in keeping a young appearance and healthy skin has leveraged the skincare industry. This, coupled together with the increased concern regarding the safety of synthetic products, has boosted the demand for new and safer natural ingredients. Accordingly, the aim of this study was to evaluate the dermatological potential of the brown seaweed The antioxidant, anti-enzymatic, antimicrobial, photoprotective and anti-inflammatory properties of five fractions (F1-F5) were evaluated. The ethyl acetate fraction (F3) demonstrated the most promising results, with the best ability to scavenge 2,2-diphenyl-1-picrylhydrazyl (DPPH) radicals (EC of 140.1 µg/mL) and the capacity to reduce reactive oxygen species (ROS) production promoted by UVA and UVB radiation in 3T3 cells, revealing its antioxidant and photoprotective potential. This fraction also exhibited the highest anti-enzymatic capacity, inhibiting the activities of collagenase, elastase and tyrosinase (IC of 7.2, 4.8 and 85.9 µg/mL, respectively). Moreover, F3 showed anti-inflammatory potential, reducing TNF-α and IL-6 release induced by LPS treatment in RAW 264.7 cells. These bioactivities may be related to the presence of phenolic compounds, such as phlorotannins, as demonstrated by NMR analysis. The results highlight the potential of as a source of bioactive ingredients for further dermatological applications.
AbstractList	The ever-increasing interest in keeping a young appearance and healthy skin has leveraged the skincare industry. This, coupled together with the increased concern regarding the safety of synthetic products, has boosted the demand for new and safer natural ingredients. Accordingly, the aim of this study was to evaluate the dermatological potential of the brown seaweed Carpomitra costata. The antioxidant, anti-enzymatic, antimicrobial, photoprotective and anti-inflammatory properties of five C. costata fractions (F1–F5) were evaluated. The ethyl acetate fraction (F3) demonstrated the most promising results, with the best ability to scavenge 2,2-diphenyl-1-picrylhydrazyl (DPPH) radicals (EC 50 of 140.1 µg/mL) and the capacity to reduce reactive oxygen species (ROS) production promoted by UVA and UVB radiation in 3T3 cells, revealing its antioxidant and photoprotective potential. This fraction also exhibited the highest anti-enzymatic capacity, inhibiting the activities of collagenase, elastase and tyrosinase (IC 50 of 7.2, 4.8 and 85.9 µg/mL, respectively). Moreover, F3 showed anti-inflammatory potential, reducing TNF-α and IL-6 release induced by LPS treatment in RAW 264.7 cells. These bioactivities may be related to the presence of phenolic compounds, such as phlorotannins, as demonstrated by NMR analysis. The results highlight the potential of C. costata as a source of bioactive ingredients for further dermatological applications. The ever-increasing interest in keeping a young appearance and healthy skin has leveraged the skincare industry. This, coupled together with the increased concern regarding the safety of synthetic products, has boosted the demand for new and safer natural ingredients. Accordingly, the aim of this study was to evaluate the dermatological potential of the brown seaweed The antioxidant, anti-enzymatic, antimicrobial, photoprotective and anti-inflammatory properties of five fractions (F1-F5) were evaluated. The ethyl acetate fraction (F3) demonstrated the most promising results, with the best ability to scavenge 2,2-diphenyl-1-picrylhydrazyl (DPPH) radicals (EC of 140.1 µg/mL) and the capacity to reduce reactive oxygen species (ROS) production promoted by UVA and UVB radiation in 3T3 cells, revealing its antioxidant and photoprotective potential. This fraction also exhibited the highest anti-enzymatic capacity, inhibiting the activities of collagenase, elastase and tyrosinase (IC of 7.2, 4.8 and 85.9 µg/mL, respectively). Moreover, F3 showed anti-inflammatory potential, reducing TNF-α and IL-6 release induced by LPS treatment in RAW 264.7 cells. These bioactivities may be related to the presence of phenolic compounds, such as phlorotannins, as demonstrated by NMR analysis. The results highlight the potential of as a source of bioactive ingredients for further dermatological applications. The ever-increasing interest in keeping a young appearance and healthy skin has leveraged the skincare industry. This, coupled together with the increased concern regarding the safety of synthetic products, has boosted the demand for new and safer natural ingredients. Accordingly, the aim of this study was to evaluate the dermatological potential of the brown seaweed Carpomitra costata. The antioxidant, anti-enzymatic, antimicrobial, photoprotective and anti-inflammatory properties of five C. costata fractions (F1–F5) were evaluated. The ethyl acetate fraction (F3) demonstrated the most promising results, with the best ability to scavenge 2,2-diphenyl-1-picrylhydrazyl (DPPH) radicals (EC50 of 140.1 µg/mL) and the capacity to reduce reactive oxygen species (ROS) production promoted by UVA and UVB radiation in 3T3 cells, revealing its antioxidant and photoprotective potential. This fraction also exhibited the highest anti-enzymatic capacity, inhibiting the activities of collagenase, elastase and tyrosinase (IC50 of 7.2, 4.8 and 85.9 µg/mL, respectively). Moreover, F3 showed anti-inflammatory potential, reducing TNF-α and IL-6 release induced by LPS treatment in RAW 264.7 cells. These bioactivities may be related to the presence of phenolic compounds, such as phlorotannins, as demonstrated by NMR analysis. The results highlight the potential of C. costata as a source of bioactive ingredients for further dermatological applications.
Author	Pedrosa, Rui Petrovski, Željko Goettert, Márcia Ines Mouga, Teresa Susano, Patrícia Silva, Joana Branco, Luís B Pinteus, Susete Alves, Celso Martins, Alice Gaspar, Helena
AuthorAffiliation	4 Cell Culture Laboratory, Postgraduate Programme in Biotechnology, University of Vale do Taquari-Univates, Lajeado, RS 95914-014, Brazil; marcia.goettert@univates.br 5 LAQV-REQUIMTE, Departamento de Química, Faculdade de Ciências e Tecnologia da Universidade Nova de Lisboa, 2829-516 Caparica, Portugal; z.petrovski@fct.unl.pt (Ž.P.); l.branco@fct.unl.pt (L.B.B.) 3 MARE—Marine and Environmental Sciences Centre, ESTM, Polytechnic of Leiria, 2520-614 Peniche, Portugal; mougat@ipleiria.pt 1 MARE—Marine and Environmental Sciences Centre, Polytechnic of Leiria, 2520-630 Peniche, Portugal; patricia_susano94@hotmail.com (P.S.); joana.m.silva@ipleiria.pt (J.S.); alice.martins@ipleiria.pt (A.M.); hmgaspar@fc.ul.pt (H.G.); susete.pinteus@ipleiria.pt (S.P.) 2 BioISI-Biosystems and Integrative Sciences Institute, Faculty of Sciences, University of Lisbon, 1749-016 Lisboa, Portugal
AuthorAffiliation_xml	– name: 4 Cell Culture Laboratory, Postgraduate Programme in Biotechnology, University of Vale do Taquari-Univates, Lajeado, RS 95914-014, Brazil; marcia.goettert@univates.br – name: 3 MARE—Marine and Environmental Sciences Centre, ESTM, Polytechnic of Leiria, 2520-614 Peniche, Portugal; mougat@ipleiria.pt – name: 1 MARE—Marine and Environmental Sciences Centre, Polytechnic of Leiria, 2520-630 Peniche, Portugal; patricia_susano94@hotmail.com (P.S.); joana.m.silva@ipleiria.pt (J.S.); alice.martins@ipleiria.pt (A.M.); hmgaspar@fc.ul.pt (H.G.); susete.pinteus@ipleiria.pt (S.P.) – name: 2 BioISI-Biosystems and Integrative Sciences Institute, Faculty of Sciences, University of Lisbon, 1749-016 Lisboa, Portugal – name: 5 LAQV-REQUIMTE, Departamento de Química, Faculdade de Ciências e Tecnologia da Universidade Nova de Lisboa, 2829-516 Caparica, Portugal; z.petrovski@fct.unl.pt (Ž.P.); l.branco@fct.unl.pt (L.B.B.)
Author_xml	– sequence: 1 givenname: Patrícia surname: Susano fullname: Susano, Patrícia organization: MARE-Marine and Environmental Sciences Centre, Polytechnic of Leiria, 2520-630 Peniche, Portugal – sequence: 2 givenname: Joana orcidid: 0000-0003-1224-1699 surname: Silva fullname: Silva, Joana organization: MARE-Marine and Environmental Sciences Centre, Polytechnic of Leiria, 2520-630 Peniche, Portugal – sequence: 3 givenname: Celso orcidid: 0000-0003-1581-2127 surname: Alves fullname: Alves, Celso organization: MARE-Marine and Environmental Sciences Centre, Polytechnic of Leiria, 2520-630 Peniche, Portugal – sequence: 4 givenname: Alice surname: Martins fullname: Martins, Alice organization: MARE-Marine and Environmental Sciences Centre, Polytechnic of Leiria, 2520-630 Peniche, Portugal – sequence: 5 givenname: Helena orcidid: 0000-0002-3290-3111 surname: Gaspar fullname: Gaspar, Helena organization: BioISI-Biosystems and Integrative Sciences Institute, Faculty of Sciences, University of Lisbon, 1749-016 Lisboa, Portugal – sequence: 6 givenname: Susete orcidid: 0000-0003-4849-8840 surname: Pinteus fullname: Pinteus, Susete organization: MARE-Marine and Environmental Sciences Centre, Polytechnic of Leiria, 2520-630 Peniche, Portugal – sequence: 7 givenname: Teresa orcidid: 0000-0002-1613-7023 surname: Mouga fullname: Mouga, Teresa organization: MARE-Marine and Environmental Sciences Centre, ESTM, Polytechnic of Leiria, 2520-614 Peniche, Portugal – sequence: 8 givenname: Márcia Ines surname: Goettert fullname: Goettert, Márcia Ines organization: Cell Culture Laboratory, Postgraduate Programme in Biotechnology, University of Vale do Taquari-Univates, Lajeado, RS 95914-014, Brazil – sequence: 9 givenname: Željko orcidid: 0000-0002-8104-7008 surname: Petrovski fullname: Petrovski, Željko organization: LAQV-REQUIMTE, Departamento de Química, Faculdade de Ciências e Tecnologia da Universidade Nova de Lisboa, 2829-516 Caparica, Portugal – sequence: 10 givenname: Luís B surname: Branco fullname: Branco, Luís B organization: LAQV-REQUIMTE, Departamento de Química, Faculdade de Ciências e Tecnologia da Universidade Nova de Lisboa, 2829-516 Caparica, Portugal – sequence: 11 givenname: Rui surname: Pedrosa fullname: Pedrosa, Rui organization: MARE-Marine and Environmental Sciences Centre, ESTM, Polytechnic of Leiria, 2520-614 Peniche, Portugal
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Keywords	antimicrobial antioxidant skincare anti-inflammatory phenolic compounds photoprotective algae anti-enzymatic marine natural products
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Snippet	The ever-increasing interest in keeping a young appearance and healthy skin has leveraged the skincare industry. This, coupled together with the increased...
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SubjectTerms	3T3 Cells algae Animals anti-enzymatic anti-inflammatory Anti-Inflammatory Agents - isolation & purification Anti-Inflammatory Agents - pharmacology antimicrobial antioxidant Antioxidants - isolation & purification Antioxidants - pharmacology Dermatologic Agents - isolation & purification Dermatologic Agents - pharmacology Free Radical Scavengers - isolation & purification Free Radical Scavengers - pharmacology Inhibitory Concentration 50 marine natural products Mice Phaeophyceae - chemistry Phenols - isolation & purification Phenols - pharmacology RAW 264.7 Cells Reactive Oxygen Species - metabolism
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Title	Unravelling the Dermatological Potential of the Brown Seaweed Carpomitra costata
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