Evaluation of presumptive biomarkers of oxidative stress, immune response and apoptosis in primary open-angle glaucoma

Highlights ► Oxidative stress, immune response and apoptosis in POAG initiation and progression. ► Putative glaucoma biomarkers are MDA, TAS, 8-OH-dG, ILs-1α/6, Cas-2/3/14 and PARP-1. ► Certain antibodies and cytokines vary in relation to POAG in aqueous humor and serum. ► Apoptosis biomarkers from...

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Bibliographic Details
Published in:	Current opinion in pharmacology Vol. 13; no. 1; pp. 98 - 107
Main Authors:	Pinazo-Durán, Maria D, Zanón-Moreno, Vicente, García-Medina, Jose J, Gallego-Pinazo, Roberto
Format:	Journal Article
Language:	English
Published:	England Elsevier Ltd 01-02-2013
Subjects:	Animals Apoptosis biomarkers Biomarkers - metabolism Blindness Glaucoma Glaucoma, Open-Angle - immunology Glaucoma, Open-Angle - metabolism Humans Immune response Inflammation Inflammation - immunology Inflammation - metabolism Internal Medicine Medical Education Oxidative Stress Reactive oxygen species Reviews Signal transduction
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Summary:	Highlights ► Oxidative stress, immune response and apoptosis in POAG initiation and progression. ► Putative glaucoma biomarkers are MDA, TAS, 8-OH-dG, ILs-1α/6, Cas-2/3/14 and PARP-1. ► Certain antibodies and cytokines vary in relation to POAG in aqueous humor and serum. ► Apoptosis biomarkers from blood and virtually every ocular sample might apply to POAG. ► Advances in biotechnology offer remarkable opportunities for glaucoma research.
Bibliography:	ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-1 content type line 23 ObjectType-Feature-3 ObjectType-Review-1
ISSN:	1471-4892 1471-4973
DOI:	10.1016/j.coph.2012.10.007