Salivary IL-6 mRNA is a Robust Biomarker in Oral Squamous Cell Carcinoma
Salivary IL-6 mRNA was previously identified as a promising biomarker of oral squamous cell carcinoma (OSCC). We performed a multi-center investigation covering all geographic areas of Hungary. Saliva from 95 patients with OSCC and 80 controls, all Caucasian, were collected together with demographic...
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| Published in: | Journal of clinical medicine Vol. 8; no. 11; p. 1958 |
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| Main Authors: | , , , , , , , , , , , , , , , , , |
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| Abstract | Salivary IL-6 mRNA was previously identified as a promising biomarker of oral squamous cell carcinoma (OSCC). We performed a multi-center investigation covering all geographic areas of Hungary. Saliva from 95 patients with OSCC and 80 controls, all Caucasian, were collected together with demographic and clinicopathological data. Salivary IL-6 mRNA was quantified by real-time quantitative PCR. Salivary IL-6 protein concentration was measured by enzyme-linked immune-sorbent assay. IL-6 protein expression in tumor samples was investigated by immunohistochemistry. Normalized salivary IL-6 mRNA expression values were significantly higher (
< 0.001) in patients with OSCC (mean ± SE: 3.301 ± 0.885) vs. controls (mean ± SE: 0.037 ± 0.012). Differences remained significant regardless of tumor stage and grade. AUC of the ROC curve was 0.9379 (
< 0.001; 95% confidence interval: 0.8973-0.9795; sensitivity: 0.945; specificity: 0.819). Salivary IL-6 protein levels were significantly higher (
< 0.001) in patients (mean ± SE: 70.98 ± 14.06 pg/mL), than in controls (mean ± SE: 12.45 ± 3.29). Specificity and sensitivity of IL-6 protein were less favorable than that of IL-6 mRNA. Salivary IL-6 mRNA expression was significantly associated with age and dental status. IL-6 manifestation was detected in tumor cells and tumor-infiltrating leukocytes, suggesting the presence of a paracrine loop of stimulation. Salivary IL-6 mRNA is one of the best performing and clinically relevant biomarkers of OSCC. |
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| AbstractList | Salivary IL-6 mRNA was previously identified as a promising biomarker of oral squamous cell carcinoma (OSCC). We performed a multi-center investigation covering all geographic areas of Hungary. Saliva from 95 patients with OSCC and 80 controls, all Caucasian, were collected together with demographic and clinicopathological data. Salivary IL-6 mRNA was quantified by real-time quantitative PCR. Salivary IL-6 protein concentration was measured by enzyme-linked immune-sorbent assay. IL-6 protein expression in tumor samples was investigated by immunohistochemistry. Normalized salivary IL-6 mRNA expression values were significantly higher (
< 0.001) in patients with OSCC (mean ± SE: 3.301 ± 0.885) vs. controls (mean ± SE: 0.037 ± 0.012). Differences remained significant regardless of tumor stage and grade. AUC of the ROC curve was 0.9379 (
< 0.001; 95% confidence interval: 0.8973-0.9795; sensitivity: 0.945; specificity: 0.819). Salivary IL-6 protein levels were significantly higher (
< 0.001) in patients (mean ± SE: 70.98 ± 14.06 pg/mL), than in controls (mean ± SE: 12.45 ± 3.29). Specificity and sensitivity of IL-6 protein were less favorable than that of IL-6 mRNA. Salivary IL-6 mRNA expression was significantly associated with age and dental status. IL-6 manifestation was detected in tumor cells and tumor-infiltrating leukocytes, suggesting the presence of a paracrine loop of stimulation. Salivary IL-6 mRNA is one of the best performing and clinically relevant biomarkers of OSCC. Salivary IL-6 mRNA was previously identified as a promising biomarker of oral squamous cell carcinoma (OSCC). We performed a multi-center investigation covering all geographic areas of Hungary. Saliva from 95 patients with OSCC and 80 controls, all Caucasian, were collected together with demographic and clinicopathological data. Salivary IL-6 mRNA was quantified by real-time quantitative PCR. Salivary IL-6 protein concentration was measured by enzyme-linked immune-sorbent assay. IL-6 protein expression in tumor samples was investigated by immunohistochemistry. Normalized salivary IL-6 mRNA expression values were significantly higher (p < 0.001) in patients with OSCC (mean ± SE: 3.301 ± 0.885) vs. controls (mean ± SE: 0.037 ± 0.012). Differences remained significant regardless of tumor stage and grade. AUC of the ROC curve was 0.9379 (p < 0.001; 95% confidence interval: 0.8973–0.9795; sensitivity: 0.945; specificity: 0.819). Salivary IL-6 protein levels were significantly higher (p < 0.001) in patients (mean ± SE: 70.98 ± 14.06 pg/mL), than in controls (mean ± SE: 12.45 ± 3.29). Specificity and sensitivity of IL-6 protein were less favorable than that of IL-6 mRNA. Salivary IL-6 mRNA expression was significantly associated with age and dental status. IL-6 manifestation was detected in tumor cells and tumor-infiltrating leukocytes, suggesting the presence of a paracrine loop of stimulation. Salivary IL-6 mRNA is one of the best performing and clinically relevant biomarkers of OSCC. Salivary IL-6 mRNA was previously identified as a promising biomarker of oral squamous cell carcinoma (OSCC). We performed a multi-center investigation covering all geographic areas of Hungary. Saliva from 95 patients with OSCC and 80 controls, all Caucasian, were collected together with demographic and clinicopathological data. Salivary IL-6 mRNA was quantified by real-time quantitative PCR. Salivary IL-6 protein concentration was measured by enzyme-linked immune-sorbent assay. IL-6 protein expression in tumor samples was investigated by immunohistochemistry. Normalized salivary IL-6 mRNA expression values were significantly higher ( p < 0.001) in patients with OSCC (mean ± SE: 3.301 ± 0.885) vs. controls (mean ± SE: 0.037 ± 0.012). Differences remained significant regardless of tumor stage and grade. AUC of the ROC curve was 0.9379 ( p < 0.001; 95% confidence interval: 0.8973–0.9795; sensitivity: 0.945; specificity: 0.819). Salivary IL-6 protein levels were significantly higher ( p < 0.001) in patients (mean ± SE: 70.98 ± 14.06 pg/mL), than in controls (mean ± SE: 12.45 ± 3.29). Specificity and sensitivity of IL-6 protein were less favorable than that of IL-6 mRNA. Salivary IL-6 mRNA expression was significantly associated with age and dental status. IL-6 manifestation was detected in tumor cells and tumor-infiltrating leukocytes, suggesting the presence of a paracrine loop of stimulation. Salivary IL-6 mRNA is one of the best performing and clinically relevant biomarkers of OSCC. |
| Author | Olasz, Lajos Dezső, Balázs Csősz, Éva Tőzsér, József Barabás, József Márton, Ildikó Judit Lábiscsák, Péter Szabó, Adrienn Scholtz, Beáta Tar, Ildikó Sándor, János Horváth, József Jakus, Petra Piffkó, József Barabás, Péter Kövér, Zsanett Kiss, Csongor Márkus, Bernadett |
| AuthorAffiliation | 7 Department of Maxillofacial Surgery, Semmelweis University, 1085 Budapest, Hungary; barabas.jozsef@dent.semmelweis-univ.hu (J.B.); dr.barabas.peter@gmail.com (P.B.) 5 Department of Oral Medicine, Faculty of Dentistry, University of Debrecen, 4032 Debrecen, Hungary; tar.ildiko@dental.unideb.hu 3 Department of Oral Pathology and Microbiology, Faculty of Dentistry and Institute of Pathology, University of Debrecen, 4032 Debrecen, Hungary; dezsob51@gmail.com 4 Department of Maxillofacial Surgery, University of Debrecen, 4032 Debrecen, Hungary; szabo.adrienn@dental.unideb.hu 6 Department of Maxillofacial Surgery, University of Szeged, 6720 Szeged, Hungary; piffkojozsef@gmail.com (J.P.); jakus.petra.87@gmail.com (P.J.) 9 Department of Preventive Medicine, University of Debrecen, 4028 Debrecen, Hungary; sandor.janos@sph.unideb.hu 2 Department of Biochemistry and Molecular Biology, Faculty of Medicine, University of Debrecen, 4032 Debrecen, Hungary; horvathjozsef21@gmail.com (J.H.); labiscsak.pete |
| AuthorAffiliation_xml | – name: 9 Department of Preventive Medicine, University of Debrecen, 4028 Debrecen, Hungary; sandor.janos@sph.unideb.hu – name: 1 Department of Operative Dentistry and Endodontics, Faculty of Dentistry, University of Debrecen, 4032 Debrecen, Hungary – name: 7 Department of Maxillofacial Surgery, Semmelweis University, 1085 Budapest, Hungary; barabas.jozsef@dent.semmelweis-univ.hu (J.B.); dr.barabas.peter@gmail.com (P.B.) – name: 10 Department of Pediatric Hematology-Oncology, Faculty of Medicine, University of Debrecen, 4032 Debrecen, Hungary; kisscs@med.unideb.hu – name: 2 Department of Biochemistry and Molecular Biology, Faculty of Medicine, University of Debrecen, 4032 Debrecen, Hungary; horvathjozsef21@gmail.com (J.H.); labiscsak.peter@med.unideb.hu (P.L.); jakob.bernadett@med.unideb.hu (B.M.); tozser@med.unideb.hu (J.T.); cseva@med.unideb.hu (É.C.); scholtz@med.unideb.hu (B.S.) – name: 5 Department of Oral Medicine, Faculty of Dentistry, University of Debrecen, 4032 Debrecen, Hungary; tar.ildiko@dental.unideb.hu – name: 8 Department of Oral and Maxillofacial Surgery, University of Pécs, 7621 Pécs, Hungary; olasz.lajos@pte.hu (L.O.); kover.zsanett@pte.hu (Z.K.) – name: 3 Department of Oral Pathology and Microbiology, Faculty of Dentistry and Institute of Pathology, University of Debrecen, 4032 Debrecen, Hungary; dezsob51@gmail.com – name: 4 Department of Maxillofacial Surgery, University of Debrecen, 4032 Debrecen, Hungary; szabo.adrienn@dental.unideb.hu – name: 6 Department of Maxillofacial Surgery, University of Szeged, 6720 Szeged, Hungary; piffkojozsef@gmail.com (J.P.); jakus.petra.87@gmail.com (P.J.) |
| Author_xml | – sequence: 1 givenname: Ildikó Judit surname: Márton fullname: Márton, Ildikó Judit organization: Department of Operative Dentistry and Endodontics, Faculty of Dentistry, University of Debrecen, 4032 Debrecen, Hungary – sequence: 2 givenname: József surname: Horváth fullname: Horváth, József organization: Department of Biochemistry and Molecular Biology, Faculty of Medicine, University of Debrecen, 4032 Debrecen, Hungary – sequence: 3 givenname: Péter surname: Lábiscsák fullname: Lábiscsák, Péter organization: Department of Biochemistry and Molecular Biology, Faculty of Medicine, University of Debrecen, 4032 Debrecen, Hungary – sequence: 4 givenname: Bernadett surname: Márkus fullname: Márkus, Bernadett organization: Department of Biochemistry and Molecular Biology, Faculty of Medicine, University of Debrecen, 4032 Debrecen, Hungary – sequence: 5 givenname: Balázs surname: Dezső fullname: Dezső, Balázs organization: Department of Oral Pathology and Microbiology, Faculty of Dentistry and Institute of Pathology, University of Debrecen, 4032 Debrecen, Hungary – sequence: 6 givenname: Adrienn surname: Szabó fullname: Szabó, Adrienn organization: Department of Maxillofacial Surgery, University of Debrecen, 4032 Debrecen, Hungary – sequence: 7 givenname: Ildikó surname: Tar fullname: Tar, Ildikó organization: Department of Oral Medicine, Faculty of Dentistry, University of Debrecen, 4032 Debrecen, Hungary – sequence: 8 givenname: József surname: Piffkó fullname: Piffkó, József organization: Department of Maxillofacial Surgery, University of Szeged, 6720 Szeged, Hungary – sequence: 9 givenname: Petra surname: Jakus fullname: Jakus, Petra organization: Department of Maxillofacial Surgery, University of Szeged, 6720 Szeged, Hungary – sequence: 10 givenname: József surname: Barabás fullname: Barabás, József organization: Department of Maxillofacial Surgery, Semmelweis University, 1085 Budapest, Hungary – sequence: 11 givenname: Péter surname: Barabás fullname: Barabás, Péter organization: Department of Maxillofacial Surgery, Semmelweis University, 1085 Budapest, Hungary – sequence: 12 givenname: Lajos surname: Olasz fullname: Olasz, Lajos organization: Department of Oral and Maxillofacial Surgery, University of Pécs, 7621 Pécs, Hungary – sequence: 13 givenname: Zsanett surname: Kövér fullname: Kövér, Zsanett organization: Department of Oral and Maxillofacial Surgery, University of Pécs, 7621 Pécs, Hungary – sequence: 14 givenname: József orcidid: 0000-0001-5076-8729 surname: Tőzsér fullname: Tőzsér, József organization: Department of Biochemistry and Molecular Biology, Faculty of Medicine, University of Debrecen, 4032 Debrecen, Hungary – sequence: 15 givenname: János surname: Sándor fullname: Sándor, János organization: Department of Preventive Medicine, University of Debrecen, 4028 Debrecen, Hungary – sequence: 16 givenname: Éva orcidid: 0000-0003-4373-2175 surname: Csősz fullname: Csősz, Éva organization: Department of Biochemistry and Molecular Biology, Faculty of Medicine, University of Debrecen, 4032 Debrecen, Hungary – sequence: 17 givenname: Beáta surname: Scholtz fullname: Scholtz, Beáta organization: Department of Biochemistry and Molecular Biology, Faculty of Medicine, University of Debrecen, 4032 Debrecen, Hungary – sequence: 18 givenname: Csongor surname: Kiss fullname: Kiss, Csongor organization: Department of Pediatric Hematology-Oncology, Faculty of Medicine, University of Debrecen, 4032 Debrecen, Hungary |
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| Keywords | oral neoplasia enzyme-linked immune-sorbent assay ethanol consumption smoking periodontal disease/periodontitis immunohistochemistry salivary biomarkers real-time quantitative PCR |
| Language | English |
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| Title | Salivary IL-6 mRNA is a Robust Biomarker in Oral Squamous Cell Carcinoma |
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