The regulation of the homeostasis and regeneration of peripheral nerve is distinct from the CNS and independent of a stem cell population

• Published in: Development (Cambridge) Vol. 145; no. 24
• Main Authors: Stierli, Salome, Napoli, Ilaria, White, Ian J, Cattin, Anne-Laure, Monteza Cabrejos, Anthony, Garcia Calavia, Noelia, Malong, Liza, Ribeiro, Sara, Nihouarn, Julie, Williams, Richard, Young, Kaylene M, Richardson, William D, Lloyd, Alison C
• Format: Journal Article
• Language: English
• Published: England The Company of Biologists Ltd 14-12-2018
• Subjects: Animals; Axons - metabolism; Carcinogenesis - pathology; Cell Proliferation; Central Nervous System - physiology; Extracellular Matrix Proteins - metabolism; Homeostasis; Mice, Inbred C57BL; Mice, Transgenic; Myelin Sheath - metabolism; Nerve Regeneration - physiology; Neural Stem Cells - cytology; Neural Stem Cells - metabolism; Neuronal Plasticity; Peripheral Nerves - cytology; Peripheral Nerves - physiology; Peripheral Nerves - ultrastructure; Schwann Cells - metabolism; Stem Cells and Regeneration; CNS; Tissue homeostasis; PNS; Tissue regeneration; Schwann cells; Stem cells
• DOI: 10.1242/dev.170316
• EISSN: 1477-9129
• ISSN: 0950-1991

Peripheral nerves are highly regenerative, in contrast to the poor regenerative capabilities of the central nervous system (CNS). Here, we show that adult peripheral nerve is a more quiescent tissue than the CNS, yet all cell types within a peripheral nerve proliferate efficiently following injury. Moreover, whereas oligodendrocytes are produced throughout life from a precursor pool, we find that the corresponding cell of the peripheral nervous system, the myelinating Schwann cell (mSC), does not turn over in the adult. However, following injury, all mSCs can dedifferentiate to the proliferating progenitor-like Schwann cells (SCs) that orchestrate the regenerative response. Lineage analysis shows that these newly migratory, progenitor-like cells redifferentiate to form new tissue at the injury site and maintain their lineage, but can switch to become a non-myelinating SC. In contrast, increased plasticity is observed during tumourigenesis. These findings show that peripheral nerves have a distinct mechanism for maintaining homeostasis and can regenerate without the need for an additional stem cell population.This article has an associated 'The people behind the papers' interview.