MicroRNA-145 repairs infarcted myocardium by accelerating cardiomyocyte autophagy

We investigated whether microRNA-145 (miR-145) has a cardioprotective effect in a rabbit model of myocardial infarction (MI) and in H9c2 rat cardiomyoblasts. Rabbits underwent 30 min of coronary occlusion, followed by 2 days or 2 wk of reperfusion. Control microRNA (control group; 2.5 nmol/kg, n = 1...

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Bibliographic Details
Published in:	American journal of physiology. Heart and circulatory physiology Vol. 309; no. 11; p. H1813
Main Authors:	Higashi, Kenshi, Yamada, Yoshihisa, Minatoguchi, Shingo, Baba, Shinya, Iwasa, Masamitsu, Kanamori, Hiromitsu, Kawasaki, Masanori, Nishigaki, Kazuhiko, Takemura, Genzou, Kumazaki, Minami, Akao, Yukihiro, Minatoguchi, Shinya
Format:	Journal Article
Language:	English
Published:	United States 01-12-2015
Subjects:	Adaptor Proteins, Signal Transducing - genetics Adaptor Proteins, Signal Transducing - metabolism Animals Autophagy Cell Line Disease Models, Animal Genetic Therapy - methods Kruppel-Like Transcription Factors - metabolism Male MicroRNAs - administration & dosage MicroRNAs - genetics MicroRNAs - metabolism Microtubule-Associated Proteins - metabolism Myocardial Infarction - genetics Myocardial Infarction - metabolism Myocardial Infarction - pathology Myocardial Infarction - physiopathology Myocardial Infarction - therapy Myocytes, Cardiac - metabolism Myocytes, Cardiac - pathology Phosphorylation Proto-Oncogene Proteins c-akt - metabolism Rabbits Rats RNA Interference RNA, Messenger - metabolism Signal Transduction Time Factors Transfection Ventricular Function, Left Ventricular Remodeling autophagy cardiomyocyte miR-145 myocardial infarction
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