Anxiogenesis induced by nitric oxide synthase inhibition and anxiolytic effect of melanin-concentrating hormone (MCH) in rat brain

In this study, the involvement of nitric oxide (NO) in the mechanism of anxiety was investigated. The rats received an intraamygdaline or intrahippocampal injection of the nitric oxide synthase inhibitor, N G-nitro-l-arginine (L-NOARG), and were then tested in the plus-maze test. L-NOARG induced a d...

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Bibliographic Details
Published in:	Peptides (New York, N.Y. : 1980) Vol. 22; no. 7; pp. 1043 - 1047
Main Authors:	Monzón, M.E, Varas, M.M, De Barioglio, S.R
Format:	Journal Article
Language:	English
Published:	United States Elsevier Inc 01-07-2001
Subjects:	Amygdala - drug effects Amygdala - enzymology Animals Brain - enzymology Enzyme Inhibitors - pharmacology Hippocampus - drug effects Hippocampus - enzymology Hypothalamic Hormones - pharmacology L-NOARG Male Maze Learning - drug effects Melanins - pharmacology Neovascularization, Pathologic Nitric Oxide - metabolism Nitric Oxide Synthase - antagonists & inhibitors Nitroarginine - pharmacology Oxygen - metabolism Pituitary Hormones - pharmacology Rats Rats, Wistar Time Factors
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