From the distinctive smell to therapeutic effects: Garlic for cardiovascular, hepatic, gut, diabetes and chronic kidney disease

• Published in: Clinical nutrition (Edinburgh, Scotland) Vol. 40; no. 7; pp. 4807 - 4819
• Main Authors: Ribeiro, Marcia, Alvarenga, Livia, Cardozo, Ludmila F.M.F., Chermut, Tuany R., Sequeira, Joana, de Souza Gouveia Moreira, Laís, Teixeira, Karla Thaís Resende, Shiels, Paul G., Stenvinkel, Peter, Mafra, Denise
• Format: Journal Article
• Language: English
• Published: England Elsevier Ltd 01-07-2021
• Subjects: Anti-Inflammatory Agents - administration & dosage; Antioxidants - administration & dosage; Cardiovascular Diseases - prevention & control; Chronic kidney disease; Dysbiosis - therapy; Garlic; Gastrointestinal Microbiome - drug effects; Gut microbiota; Humans; Inflammation; Medicin och hälsovetenskap; Oxidative stress; Protective Agents - administration & dosage; Renal Insufficiency, Chronic - therapy; Gut microbiota; Oxidative stress; Chronic kidney disease; Garlic; Inflammation
• ISSN: 0261-5614; 1532-1983; 1532-1983
• DOI: 10.1016/j.clnu.2021.03.005

Garlic, a member of the Allium family, widely used in cooking for many centuries, displays well described antioxidant and anti-inflammatory properties, as a result of its constituent organosulfur compounds, such as alliin, allicin, ajoene S-allyl-cysteine, diallyl sulfide and diallyl disulfide, among others. Although garlic has demonstrated beneficial effects in cardiovascular disease, diabetes, and cancer, its efficacy as a therapeutic intervention in chronic kidney disease remains to be proven. This review thus focuses on the potential benefits of garlic as a treatment option in chronic kidney disease. and its ability to mitigate associated cardiovascular complications and gut dysbiosis.