Aberrant hippocampal mossy fiber sprouting correlates with greater NMDAR2 receptor staining

This study determined in temporal lobe epilepsy patients and rats injected with intrahippocampal kainate (KA) whether fascia dentata molecular layer mossy fiber sprouting was associated with increases in NMDAR2 immunoreactivity (IR). Patients with hippocampal sclerosis (n = 11) were compared with th...

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Bibliographic Details
Published in:	Neuroreport Vol. 7; no. 5; p. 1029
Main Authors:	Mathern, G W, Leite, J P, Babb, T L, Pretorius, J K, Kuhlman, P A, Mendoza, D, Fried, I, Sakamoto, A C, Assirati, J A, Adelson, P D, Peacock, W J
Format:	Journal Article
Language:	English
Published:	England 10-04-1996
Subjects:	Adult Aged Analysis of Variance Animals Epilepsy, Temporal Lobe - pathology Excitatory Amino Acid Agonists - pharmacology Functional Laterality - physiology Hippocampus - drug effects Hippocampus - ultrastructure Humans Immunohistochemistry Kainic Acid - pharmacology Male Middle Aged Nerve Fibers - drug effects Nerve Fibers - ultrastructure Neurons - drug effects Neurons - ultrastructure Rats Rats, Sprague-Dawley Receptors, N-Methyl-D-Aspartate - analysis Sclerosis Staining and Labeling Synapses - physiology
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