Hypoglycemic effects of Ganoderma applanatum and Collybia confluens exo-polymers in streptozotocin-induced diabetic rats

• Published in: Phytotherapy research Vol. 21; no. 11; pp. 1066 - 1069
• Main Authors: Yang, Byung-Keun, Jung, Yu-Sun, Song, Chi-Hyun
• Format: Journal Article
• Language: English
• Published: Chichester, UK John Wiley & Sons, Ltd 01-11-2007; Wiley
• Subjects: Agaricales - chemistry; Animals; Biological and medical sciences; Biopolymers - analysis; Biopolymers - pharmacology; Biopolymers - therapeutic use; Collybia; Collybia confluens; Diabetes Mellitus, Experimental - drug therapy; Diabetes Mellitus, Experimental - pathology; Eating - drug effects; exo-polymers; Ganoderma - chemistry; Ganoderma applanatum; General pharmacology; hypoglycemic activity; Hypoglycemic Agents - analysis; Hypoglycemic Agents - pharmacology; Hypoglycemic Agents - therapeutic use; Male; Medical sciences; Medicine, East Asian Traditional; Organ Size - drug effects; Pharmacognosy. Homeopathy. Health food; Pharmacology. Drug treatments; Rats; Rats, Sprague-Dawley; submerged mycelial culture; Weight Gain - drug effects; Endocrinopathy; Antineoplastic agent; hypoglycemic activity; Rat; Pharmacognosy; Diabetes mellitus; Rodentia; Basidiomycetes; Polymer; Ganoderma applanatum; Medicinal plant; Fungi; Vertebrata; Antibiotic; Hypoglycemic agent; Mammalia; Animal; Plant origin; Collybia confluens; submerged mycelial culture; Streptozotocin; exo-polymers; Thallophyta
• ISSN: 0951-418X; 1099-1573
• DOI: 10.1002/ptr.2214

The hypoglycemic effects of Ganoderma applanatum exo-polymer (GAE) and Collybia confluens exo-polymer (CCE) produced by submerged mycelial cultures in streptozotocin (STZ)-induced diabetic rats were investigated. Hypoglycemic effects were achieved in both the GAE- and CCE-treated groups by administration at a level of 100 mg/kg body weight (BW) daily for 3 weeks. The administration of GAE and CCE substantially reduced the plasma glucose levels by as much as 22.0% and 25.9%, respectively, when compared with the control group. The GAE and CCE also lowered the plasma total cholesterol and triglyceride levels by 20.3% and 22.5%, and by 22.7% and 25.5%, respectively. Furthermore, the activity of alanine transaminase (ALT) and aspartate transaminase (AST) was decreased by 23.2% and 20.7% in the GAE-treated group, and it was also reduced by 28.7% and 23.6% in the CCE-treated group. The results strongly demonstrate the potential of GAE and CCE in combating diabetes in experimental animals. Copyright © 2007 John Wiley & Sons, Ltd.