α3β1 Integrin Suppresses Prostate Cancer Metastasis via Regulation of the Hippo Pathway

Existing anticancer strategies focused on disrupting integrin functions in tumor cells or tumor-involved endothelial cells have met limited success. An alternative strategy is to augment integrin-mediated pathways that suppress tumor progression, but how integrins can signal to restrain malignant be...

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Bibliographic Details

Published in:	Cancer research (Chicago, Ill.) Vol. 76; no. 22; pp. 6577 - 6587
Main Authors:	Varzavand, Afshin, Hacker, Will, Ma, Deqin, Gibson-Corley, Katherine, Hawayek, Maria, Tayh, Omar J, Brown, James A, Henry, Michael D, Stipp, Christopher S
Format:	Journal Article
Language:	English
Published:	United States 15-11-2016
Subjects:	Animals Cell Proliferation Humans Integrin alpha3beta1 - genetics Male Mice Neoplasm Metastasis Prostatic Neoplasms - genetics Prostatic Neoplasms - metabolism Prostatic Neoplasms - pathology Protein-Serine-Threonine Kinases - genetics Protein-Serine-Threonine Kinases - metabolism Signal Transduction
Online Access:	Get full text
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