The first genome‐wide association study in the Argentinian and Chilean populations identifies shared genetics with Europeans in Alzheimer's disease

INTRODUCTION Genome‐wide association studies (GWAS) are fundamental for identifying loci associated with diseases. However, they require replication in other ethnicities. METHODS We performed GWAS on sporadic Alzheimer's disease (AD) including 539 patients and 854 controls from Argentina and Ch...

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Published in:	Alzheimer's & dementia Vol. 20; no. 2; pp. 1298 - 1308
Main Authors:	Dalmasso, Maria Carolina, Rojas, Itziar, Olivar, Natividad, Muchnik, Carolina, Angel, Bárbara, Gloger, Sergio, Sanchez Abalos, Mariana Soledad, Chacón, María Victoria, Aránguiz, Rafael, Orellana, Paulina, Cuesta, Carolina, Galeano, Pablo, Campanelli, Lorenzo, Novack, Gisela Vanina, Martinez, Luis Eduardo, Medel, Nancy, Lisso, Julieta, Sevillano, Zulma, Irureta, Nicolás, Castaño, Eduardo Miguel, Montrreal, Laura, Thoenes, Michaela, Hanses, Claudia, Heilmann‐Heimbach, Stefanie, Kairiyama, Claudia, Mintz, Inés, Villella, Ivana, Rueda, Fabiana, Romero, Amanda, Wukitsevits, Nancy, Quiroga, Ivana, Gona, Cristian, Lambert, Jean‐Charles, Solis, Patricia, Politis, Daniel Gustavo, Mangone, Carlos Alberto, Gonzalez‐Billault, Christian, Boada, Mercè, Tàrraga, Lluís, Slachevsky, Andrea, Albala, Cecilia, Fuentes, Patricio, Kochen, Silvia, Brusco, Luis Ignacio, Ruiz, Agustín, Morelli, Laura, Ramírez, Alfredo
Format:	Journal Article
Language:	English
Published:	United States John Wiley & Sons, Inc 01-02-2024 John Wiley and Sons Inc
Subjects:	admixture Alzheimer Disease - genetics Alzheimer's disease American Indians Apolipoproteins Associations Azides Biobanks Chile Dementia Disease Ethics Genetic Predisposition to Disease - genetics genetic risk score Genetic susceptibility Genetic testing Genetics Genome-Wide Association Study Genomes Genomics Health risk assessment Hispanic Hospitals Humans Latin America Native‐American ancestry Older people Polymorphism, Single Nucleotide - genetics Population Precision medicine Quality control South America Chile Argentina Spain Latin America South America genetics admixture genome-wide association study genetic risk score Native-American ancestry Hispanic Latin America
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