Noninvasive assessment of portal hypertension in cirrhosis:Liver stiffness and beyond

Liver stiffness measurement(LSM)is a good,but still limited tool to noninvasively assess complications and prognosis in patients with advanced liver disease.This review aims to consider the role of LSM for the diagnosis of portal hypertension-related complications and for assessment of prognosis in...

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Bibliographic Details
Published in:	World journal of gastroenterology : WJG Vol. 20; no. 45; pp. 16811 - 16819
Main Authors:	Stefanescu, Horia, Procopet, Bogdan
Format:	Journal Article
Language:	English
Published:	United States Baishideng Publishing Group Inc 07-12-2014
Subjects:	Animals Biomarkers - blood Blood Pressure Determination Compli-cation Elasticity Elasticity Imaging Techniques Humans hypertension Hypertension, Portal - blood Hypertension, Portal - diagnosis Hypertension, Portal - etiology Hypertension, Portal - pathology Hypertension, Portal - physiopathology Liver Liver - metabolism Liver - pathology Liver Cirrhosis - blood Liver Cirrhosis - complications Liver Cirrhosis - diagnosis Liver Cirrhosis - pathology Portal Portal Pressure Predictive Value of Tests Prognosis Spleen - pathology stiffness Topic Highlight Complication Liver stiffness Spleen stiffness Portal hypertension Prediction
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Summary:	Liver stiffness measurement(LSM)is a good,but still limited tool to noninvasively assess complications and prognosis in patients with advanced liver disease.This review aims to consider the role of LSM for the diagnosis of portal hypertension-related complications and for assessment of prognosis in cirrhotic patients,and to highlight the drawbacks as well as some alternatives for improving the performance.Hence,this field is far from being closed,and deserves more attention.There is still a place for more carefully designed studies to find new,innovative and reliable approaches.
Bibliography:	Horia Stefanescu;Bogdan Procopet;Department of Medical and Surgical Sciences, University of Bologna;Regional Institute of Gastroenterology and Hepatology;Liver Hemodynamic Unit, Hospital Clinic;3rd Medical Clinic, Iuliu Hatieganu University of Medicine and Pharmacy ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-3 content type line 23 ObjectType-Review-1 Author contributions: Stefanescu H and Procopet B contributed equally to this manuscript; both authors approved the final version. Correspondence to: Horia Stefanescu, MD, PhD, Department of Medical and Surgical Sciences, University of Bologna, Via Albertoni 15, 40126 Bologna, Italy. horia.stefanescu@unibo.it Telephone: +40-766-318283 Fax: +40-766-318283
ISSN:	1007-9327 2219-2840
DOI:	10.3748/wjg.v20.i45.16811