Dietary flaxseed supplementation improves endothelial function in the mesenteric arterial bed

• Published in: Food research international Vol. 43; no. 8; pp. 2052 - 2056
• Main Authors: Daleprane, Julio Beltrame, Batista, Aline, Pacheco, Juliana Tomaz, da Silva, Andréa F.E., Costa, Cristiane A., Resende, Ângela de Castro, Boaventura, Gilson Teles
• Format: Journal Article
• Language: English
• Published: Kidlington Elsevier Ltd 01-10-2010; Elsevier
• Subjects: acetylcholine; Biological and medical sciences; Blood; cardioprotective effect; Diet; Diets; Endothelial function; Feeding. Feeding behavior; Fibers; Flaxseed; Food industries; Foods; Fundamental and applied biological sciences. Psychology; linseed; Lipid profile; Lipids; Mesenteric arterial bed; Proteins; Rats; Reduction; Vertebrates: anatomy and physiology, studies on body, several organs or systems; Mesenteric arterial bed; Lipid profile; Endothelial function; Flaxseed; Diet; Linseed; Lipids; Supplementation; Profile; Feeding
• ISSN: 0963-9969; 1873-7145
• DOI: 10.1016/j.foodres.2010.06.004

The aim of this study was to evaluate the influence of flaxseed diet supplementation on endothelial function in the mesenteric arterial bed of rats. Twenty-four rats were divided into 3 groups: Control Group (CG; 10% protein; 5% fiber; 7% lipid); Flaxseed Group (FG, supplemented with 25% flaxseed; 10% protein; 7% fiber; 11% lipid); and Modified Control Group (MCG; 10% protein; 7% fiber; 11% lipid). The blood was obtained by cardiac puncture (after 180
days) and the serum was separated for lipid profile analyses. The vasodilator effect of acetylcholine (1–100
pmol) was evaluated in the preconstricted isolated rat vascular bed. FG showed a 47% increase in HDL-C, a 22% reduction in LDL-C, a 23% reduction in triacylglycerols, and an increased (
p
<
0.05) vasodilator response to acetylcholine, in relation to the CG and CMG groups. These results suggest that flaxseed has a cardioprotective effect by improving the blood lipid profile and endothelial function.