Human islets expressing HNF1A variant have defective β cell transcriptional regulatory networks

Using an integrated approach to characterize the pancreatic tissue and isolated islets from a 33-year-old with 17 years of type 1 diabetes (T1D), we found that donor islets contained β cells without insulitis and lacked glucose-stimulated insulin secretion despite a normal insulin response to cAMP-e...

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Bibliographic Details
Published in:	The Journal of clinical investigation Vol. 129; no. 1; pp. 246 - 251
Main Authors:	Haliyur, Rachana, Tong, Xin, Sanyoura, May, Shrestha, Shristi, Lindner, Jill, Saunders, Diane C, Aramandla, Radhika, Poffenberger, Greg, Redick, Sambra D, Bottino, Rita, Prasad, Nripesh, Levy, Shawn E, Blind, Raymond D, Harlan, David M, Philipson, Louis H, Stein, Roland W, Brissova, Marcela, Powers, Alvin C
Format:	Journal Article
Language:	English
Published:	United States American Society for Clinical Investigation 02-01-2019
Subjects:	Adolescent Adult Beta cells Biomedical research Concise Communication Deoxyribonucleic acid Diabetes Diabetes mellitus (insulin dependent) Diabetes Mellitus, Type 1 - genetics Diabetes Mellitus, Type 1 - metabolism Diabetes Mellitus, Type 1 - pathology DNA Gene expression Genetic Variation Glucose Hepatocyte Nuclear Factor 1-alpha - biosynthesis Hepatocyte Nuclear Factor 1-alpha - genetics Heterozygote Homeostasis Humans Insulin Insulin secretion Insulin-Secreting Cells - metabolism Insulin-Secreting Cells - pathology Insulitis Male Mutation Nucleotide sequence Pancreas Proteins Secretion Transcription Transcription factors Transcription, Genetic Islet cells Diabetes Insulin Endocrinology
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