Up-regulation of gasdermin C in mouse small intestine is associated with lytic cell death in enterocytes in worm-induced type 2 immunity

“Taste-like” tuft cells in the intestine trigger type 2 immunity in response toworm infection. The secretion of interleukin-13 (IL-13) from type 2 innate lymphoid cells (ILC2) represents a key step in the tuft cell–ILC2 cell–intestinal epithelial cell circuit that drives the clearance of worms from...

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Bibliographic Details
Published in:	Proceedings of the National Academy of Sciences - PNAS Vol. 118; no. 30; pp. 1 - 9
Main Authors:	Xi, Ranhui, Montague, Julia, Lin, Xiaoli, Lu, Chanyi, Lei, Weiwei, Tanaka, Keisuke, Zhang, Yali V., Xu, Xin, Zheng, Xin, Zhou, Xuedong, Urban, Joseph F., Iwatsuki, Ken, Margolskee, Robert F., Matsumoto, Ichiro, Tizzano, Marco, Li, Jiyao, Jiang, Peihua
Format:	Journal Article
Language:	English
Published:	United States National Academy of Sciences 27-07-2021
Subjects:	Animals Antiparasitic agents Apoptosis Atrophy Biological Sciences Cell Death Cell Proliferation Circuits Clearances Cytokines Digestive system DNA-Binding Proteins - genetics DNA-Binding Proteins - metabolism Effectors Enterocytes Enterocytes - immunology Enterocytes - metabolism Enterocytes - parasitology Enterocytes - pathology Epithelial cells Epithelium Female Gastrointestinal tract Gene expression Immune clearance Immune response Immunity Immunity, Innate - immunology Interleukin 13 Interleukin 4 Interleukin-13 - metabolism Interleukin-4 - metabolism Intestine Intestine, Small - immunology Intestine, Small - metabolism Intestine, Small - parasitology Intestine, Small - pathology Lymphoid cells Male Mice Mice, Inbred C57BL Mortality Nippostrongylus - physiology Organoids Pyroptosis Signal Transduction Small intestine Strongylida Infections - complications Strongylida Infections - immunology Strongylida Infections - metabolism Strongylida Infections - parasitology Th2 Cells - immunology Up-regulation Villus IL-4/IL-13 pyroptosis gasdermin helminth type 2 immunity
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