Kinase Insert Domain Receptor Q472H Pathogenic Germline Variant Impacts Melanoma Tumor Growth and Patient Treatment Outcomes

We previously reported a higher incidence of a pathogenic germline variant in the kinase insert domain receptor (KDR) in melanoma patients compared to the general population. Here, we dissect the impact of this genotype on melanoma tumor growth kinetics, tumor phenotype, and response to treatment wi...

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Bibliographic Details
Published in:	Cancers Vol. 16; no. 1; p. 18
Main Authors:	Ibrahim, Milad, Illa-Bochaca, Irineu, Fa'ak, Faisal, Monson, Kelsey R, Ferguson, Robert, Lyu, Chen, Vega-Saenz de Miera, Eleazar, Johannet, Paul, Chou, Margaret, Mastroianni, Justin, Darvishian, Farbod, Kirchhoff, Tomas, Zhong, Judy, Krogsgaard, Michelle, Osman, Iman
Format:	Journal Article
Language:	English
Published:	Switzerland MDPI AG 19-12-2023 MDPI
Subjects:	Angiogenesis Animal models Antimitotic agents Antineoplastic agents Cancer Cancer therapies Care and treatment CD45 antigen Cell growth Clinical outcomes Clinical trials Cytotoxicity Development and progression Drug therapy Gene expression Genotypes Growth Immune checkpoint inhibitors Kinases Lymphocytes MAP kinase Medical prognosis Melanoma Microenvironments Patient outcomes Patients PD-1 protein Phenotypes Remission Tumor-infiltrating lymphocytes Tumors Vascular endothelial growth factor Vascular endothelial growth factor receptors New York United States > US KDR targeted therapy melanoma germline immune response
Online Access:	Get full text
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