A Nucleus-targeted Alternately Spliced Nix/Bnip3L Protein Isoform Modifies Nuclear Factor κB (NFκB)-mediated Cardiac Transcription

Several Bcl2 family proteins are expressed both as mitochondrial-targeted full-length and as cytosolic truncated alternately spliced isoforms. Recombinantly expressed shorter Bcl2 family isoforms can heterotypically bind to and prevent mitochondrial localization of their full-length analogs, thus su...

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Bibliographic Details
Published in:	The Journal of biological chemistry Vol. 288; no. 22; pp. 15455 - 15465
Main Authors:	Chen, Yun, Decker, Keith F., Zheng, Dali, Matkovich, Scot J., Jia, Li, Dorn, Gerald W.
Format:	Journal Article
Language:	English
Published:	United States Elsevier Inc 31-05-2013 American Society for Biochemistry and Molecular Biology
Subjects:	Active Transport, Cell Nucleus - physiology Alternative Splicing - physiology Animals Bcl-2 Family Proteins Cardiovascular Disease Cell Biology Cell Line Cell Nucleus - genetics Cell Nucleus - metabolism Gene Expression Regulation - physiology Gene Regulation Membrane Proteins - genetics Membrane Proteins - metabolism Mice Mice, Mutant Strains Mitochondrial Proteins - genetics Mitochondrial Proteins - metabolism Muscle Proteins - genetics Muscle Proteins - metabolism Myoblasts, Cardiac - cytology Myoblasts, Cardiac - metabolism NF-kappa B (NF-KB) Protein Isoforms - genetics Protein Isoforms - metabolism Proto-Oncogene Proteins - genetics Proto-Oncogene Proteins - metabolism sNix Transcription Factor RelA - genetics Transcription Factor RelA - metabolism Transcription, Genetic - physiology Tumor Necrosis Factor (TNF) Tumor Necrosis Factor-alpha - genetics Tumor Necrosis Factor-alpha - metabolism Cardiovascular Disease Gene Regulation NF-kappa B (NF-KB) Tumor Necrosis Factor (TNF) Bcl-2 Family Proteins sNix
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