Intestinal anti-spasmodic effect of a phytodrug of Psidium guajava folia in the treatment of acute diarrheic disease

• Published in: Journal of ethnopharmacology Vol. 83; no. 1; pp. 19 - 24
• Main Authors: Lozoya, Xavier, Reyes-Morales, Hortensia, Chávez-Soto, Marco A, Martı́nez-Garcı́a, Marı́a del Carmen, Soto-González, Yolanda, Doubova, Svetlana V
• Format: Journal Article
• Language: English
• Published: Shannon Elsevier Ireland Ltd 01-11-2002; Elsevier
• Subjects: Acute diarrheic disease; Acute Disease; Adult; Antidiarrheals - administration & dosage; Antidiarrheals - therapeutic use; Biological and medical sciences; Diarrhea - drug therapy; Diarrhea - pathology; Female; General pharmacology; Humans; Intestinal anti-spasmodic; Male; Medical sciences; Parasympatholytics - administration & dosage; Parasympatholytics - therapeutic use; Pharmacognosy. Homeopathy. Health food; Pharmacology. Drug treatments; Phytodrug; Phytotherapy; Plant Extracts - administration & dosage; Plant Extracts - therapeutic use; Plant Leaves; Psidium; Psidium guajava L; Treatment Outcome; Central America; Mexico; America; Phytodrug; Acute diarrheic disease; Intestinal anti-spasmodic; Psidium guajava L; Human; Pharmacognosy; Treatment efficiency; Oral administration; Antidiarrheal agent; Diarrhea; Extract; Plant leaf; Medicinal plant; Randomization; Treatment; Folk medicine; Antispasmodic agent; Psidium guajava; Dicotyledones; Angiospermae; Plant origin; Quercetin; Myrtaceae; Double blind study; Digestive diseases; Intestinal disease; Spermatophyta; Phytotherapy
• ISSN: 0378-8741; 1872-7573
• DOI: 10.1016/S0378-8741(02)00185-X

Ancestral medicinal use of guava (
Psidium guajava L. Fam.
Myrtaceae) is today supported by numerous biomedical studies concerning the properties of leaf extracts. However, insufficient clinical studies are reported on the use of this plant resource in the treatment of gastrointestinal ailments. The present work reports a randomized, double-blinded, clinical study performed to evaluate the safety and efficacy of a phytodrug (QG-5
®) developed from guava leaves, standardized in its content of quercetin and orally administered to a group of adult patients with acute diarrheic disease. Capsules containing 500 mg of the product were administered to 50 patients every 8 h during 3 days. Results obtained showed that the used guava product decreased the duration of abdominal pain in these patients.