Biodistribution of the boron carriers boronophenylalanine (BPA) and/or decahydrodecaborate (GB-10) for Boron Neutron Capture Therapy (BNCT) in an experimental model of lung metastases
BNCT was proposed for the treatment of diffuse, non-resectable tumors in the lung. We performed boron biodistribution studies with 5 administration protocols employing the boron carriers BPA and/or GB-10 in an experimental model of disseminated lung metastases in rats. All 5 protocols were non-toxic...
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| Published in: | Applied radiation and isotopes Vol. 88; pp. 94 - 98 |
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| Main Authors: | , , , , , , , , , , , , |
| Format: | Journal Article |
| Language: | English |
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01-06-2014
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| Abstract | BNCT was proposed for the treatment of diffuse, non-resectable tumors in the lung. We performed boron biodistribution studies with 5 administration protocols employing the boron carriers BPA and/or GB-10 in an experimental model of disseminated lung metastases in rats. All 5 protocols were non-toxic and showed preferential tumor boron uptake versus lung. Absolute tumor boron concentration values were therapeutically useful (25–76ppm) for 3 protocols. Dosimetric calculations indicate that BNCT at RA-3 would be potentially therapeutic without exceeding radiotolerance in the lung.
•We performed experimental boron biodistribution studies for lung metastases.•3 protocols employing BPA and GB-10 would be therapeutically useful.•BNCT at RA-3 would be potentially therapeutic for experimental lung metastases. |
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| AbstractList | BNCT was proposed for the treatment of diffuse, non-resectable tumors in the lung. We performed boron biodistribution studies with 5 administration protocols employing the boron carriers BPA and/or GB-10 in an experimental model of disseminated lung metastases in rats. All 5 protocols were non-toxic and showed preferential tumor boron uptake versus lung. Absolute tumor boron concentration values were therapeutically useful (25-76ppm) for 3 protocols. Dosimetric calculations indicate that BNCT at RA-3 would be potentially therapeutic without exceeding radiotolerance in the lung. BNCT was proposed for the treatment of diffuse, non-resectable tumors in the lung. We performed boron biodistribution studies with 5 administration protocols employing the boron carriers BPA and/or GB-10 in an experimental model of disseminated lung metastases in rats. All 5 protocols were non-toxic and showed preferential tumor boron uptake versus lung. Absolute tumor boron concentration values were therapeutically useful (25–76 ppm) for 3 protocols. Dosimetric calculations indicate that BNCT at RA-3 would be potentially therapeutic without exceeding radiotolerance in the lung. BNCT was proposed for the treatment of diffuse, non-resectable tumors in the lung. We performed boron biodistribution studies with 5 administration protocols employing the boron carriers BPA and/or GB-10 in an experimental model of disseminated lung metastases in rats. All 5 protocols were non-toxic and showed preferential tumor boron uptake versus lung. Absolute tumor boron concentration values were therapeutically useful (25–76ppm) for 3 protocols. Dosimetric calculations indicate that BNCT at RA-3 would be potentially therapeutic without exceeding radiotolerance in the lung. •We performed experimental boron biodistribution studies for lung metastases.•3 protocols employing BPA and GB-10 would be therapeutically useful.•BNCT at RA-3 would be potentially therapeutic for experimental lung metastases. |
| Author | Garabalino, M.A. Colombo, L.L. Itoiz, M.E. Schwint, A.E. Aromando, R.F. Trivillin, V.A. Monti Hughes, A. Bortolussi, S. Altieri, S. Farías, R.O. Nigg, D.W. Pozzi, E.C.C. González, S.J. |
| Author_xml | – sequence: 1 givenname: V.A. surname: Trivillin fullname: Trivillin, V.A. organization: National Atomic Energy Commission, Argentina – sequence: 2 givenname: M.A. surname: Garabalino fullname: Garabalino, M.A. organization: National Atomic Energy Commission, Argentina – sequence: 3 givenname: L.L. surname: Colombo fullname: Colombo, L.L. organization: National Research Council (CONICET), Argentina – sequence: 4 givenname: S.J. surname: González fullname: González, S.J. organization: National Atomic Energy Commission, Argentina – sequence: 5 givenname: R.O. surname: Farías fullname: Farías, R.O. organization: National Atomic Energy Commission, Argentina – sequence: 6 givenname: A. surname: Monti Hughes fullname: Monti Hughes, A. organization: National Atomic Energy Commission, Argentina – sequence: 7 givenname: E.C.C. surname: Pozzi fullname: Pozzi, E.C.C. organization: National Atomic Energy Commission, Argentina – sequence: 8 givenname: S. surname: Bortolussi fullname: Bortolussi, S. organization: Dipartimento di Fisica Nucleare e Teorica dell’ Università, Pavia and Istituto Nazionale di Fisica Nucleare (INFN), Sezione di Pavia, Italy – sequence: 9 givenname: S. surname: Altieri fullname: Altieri, S. organization: Dipartimento di Fisica Nucleare e Teorica dell’ Università, Pavia and Istituto Nazionale di Fisica Nucleare (INFN), Sezione di Pavia, Italy – sequence: 10 givenname: M.E. surname: Itoiz fullname: Itoiz, M.E. organization: National Atomic Energy Commission, Argentina – sequence: 11 givenname: R.F. surname: Aromando fullname: Aromando, R.F. organization: National Atomic Energy Commission, Argentina – sequence: 12 givenname: D.W. surname: Nigg fullname: Nigg, D.W. organization: Idaho National Laboratory, USA – sequence: 13 givenname: A.E. surname: Schwint fullname: Schwint, A.E. email: mandyschwint@gmail.com organization: National Atomic Energy Commission, Argentina |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/24360862$$D View this record in MEDLINE/PubMed https://www.osti.gov/biblio/1156920$$D View this record in Osti.gov |
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| ContentType | Journal Article |
| Copyright | 2013 Elsevier Ltd 2013 Published by Elsevier Ltd. |
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| Keywords | Lung metastases BNCT BPA Boron biodistribution studies Boron Neutron Capture Therapy GB-10 |
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| SubjectTerms | Animals BNCT Boron biodistribution studies Boron Compounds - administration & dosage Boron Compounds - pharmacokinetics Boron Neutron Capture Therapy Boron Neutron Capture Therapy - methods BPA Cell Line, Tumor Drug Combinations GB-10 GENERAL AND MISCELLANEOUS Lung metastas Lung metastases Lung Neoplasms - metabolism Lung Neoplasms - radiotherapy Lung Neoplasms - secondary Metabolic Clearance Rate Organ Specificity Phenylalanine - administration & dosage Phenylalanine - analogs & derivatives Phenylalanine - pharmacokinetics Radiotherapy Dosage Rats Tissue Distribution |
| Title | Biodistribution of the boron carriers boronophenylalanine (BPA) and/or decahydrodecaborate (GB-10) for Boron Neutron Capture Therapy (BNCT) in an experimental model of lung metastases |
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