Stiff Collagen Matrices Increase Tumorigenic Prolactin Signaling in Breast Cancer Cells

Clinically, circulating prolactin levels and density of the extracellular matrix (ECM) are individual risk factors for breast cancer. As tumors develop, the surrounding stroma responds with increased deposition and cross-linking of the collagen matrix (desmoplasia). In mouse models, prolactin promot...

Full description

Saved in:

Bibliographic Details
Published in:	The Journal of biological chemistry Vol. 288; no. 18; pp. 12722 - 12732
Main Authors:	Barcus, Craig E., Keely, Patricia J., Eliceiri, Kevin W., Schuler, Linda A.
Format:	Journal Article
Language:	English
Published:	United States Elsevier Inc 03-05-2013 American Society for Biochemistry and Molecular Biology
Subjects:	Animals Breast Cancer Breast Neoplasms - genetics Breast Neoplasms - metabolism Breast Neoplasms - pathology Cell Biology Cell Line, Tumor Collagen Collagen Type I - genetics Collagen Type I - metabolism Density Desmoplasia Extracellular Matrix Extracellular Matrix - genetics Extracellular Matrix - metabolism Extracellular Matrix - pathology Female Focal Adhesion Kinase Focal Adhesion Kinase 1 - genetics Focal Adhesion Kinase 1 - metabolism GRB2 Adaptor Protein - genetics GRB2 Adaptor Protein - metabolism Humans Mammary Neoplasms, Animal - genetics Mammary Neoplasms, Animal - metabolism Mammary Neoplasms, Animal - pathology MAP Kinase Signaling System Mice Mitogen-Activated Protein Kinase 1 - genetics Mitogen-Activated Protein Kinase 1 - metabolism Mitogen-Activated Protein Kinase 3 - genetics Mitogen-Activated Protein Kinase 3 - metabolism Neoplasm Proteins - genetics Neoplasm Proteins - metabolism Phosphorylation - genetics Prolactin Prolactin - genetics Prolactin - metabolism STAT5 Transcription Factor - genetics STAT5 Transcription Factor - metabolism Desmoplasia Extracellular Matrix Prolactin Collagen Focal Adhesion Kinase Breast Cancer Density
Online Access:	Get full text
Tags:	Add Tag No Tags, Be the first to tag this record!

Be the first to leave a comment!