Repeat administration of DNA/liposomes to the nasal epithelium of patients with cystic fibrosis

The major cause of mortality in patients with cystic fibrosis (CF) is lung disease. Expression of the cystic fibrosis transmembrane conductance regulator (CFTR) gene product in the airways is a potential treatment. Clinical studies in which the CFTR cDNA was delivered to the respiratory epithelia of...

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Bibliographic Details
Published in:	Gene therapy Vol. 7; no. 13; pp. 1156 - 1165
Main Authors:	HYDE, S. C, SOUTHERN, K. W, EGAN, J. J, SORGI, F. L, HUANG, L, CUTHBERT, A. W, EVANS, M. J, COLLEDGE, W. H, HIGGINS, C. F, WEBB, A. K, GILL, D. R, GILEADI, U, FITZJOHN, E. M, MOFFORD, K. A, WADDELL, B. E, GOOI, H. C, GODDARD, C. A, HANNAVY, K, SMYTH, S. E
Format:	Journal Article
Language:	English
Published:	Basingstoke Nature Publishing Group 01-07-2000
Subjects:	Adolescent Adult Bacterial Adhesion Biological and medical sciences Biotechnology CFTR protein Cholesterol - analogs & derivatives Cystic fibrosis Cystic Fibrosis - immunology Cystic Fibrosis - therapy Cystic fibrosis transmembrane conductance regulator Cystic Fibrosis Transmembrane Conductance Regulator - analysis Cystic Fibrosis Transmembrane Conductance Regulator - genetics Deoxyribonucleic acid DNA Double-Blind Method Epithelial cells Epithelium Epithelium - chemistry Expression vectors Female Fundamental and applied biological sciences. Psychology Gene Expression Gene therapy Gene transfer Genetic Therapy - methods Genetic Vectors - administration & dosage Health. Pharmaceutical industry Humans Immunohistochemistry Industrial applications and implications. Economical aspects Liposomes Lung diseases Male Nasal Mucosa - chemistry Patients Phosphatidylethanolamines Quantitation Toxicity Treatment Outcome Human Immune response Respiratory disease Liposome Cystic fibrosis Gene expression Genetic disease Genetic transfer Multiple dose Gene DNA Digestive diseases Epithelial cell Clinical trial Molecular complex Cystic fibrosis transmembrane conductance regulator Gene therapy Vector Pancreatic disease
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