Toll-like receptor 7 stimulation promotes autoimmune diabetes in the NOD mouse

Aims/hypothesis The role of Toll-like receptor 7 (TLR7), a sensor of viral and self RNA, in promoting autoimmune diabetes remains unclear. Our goal was to determine the effect of TLR7 stimulation on the priming and activation of diabetogenic CD8 + T cells. Methods We explored the effects of CL097 (T...

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Bibliographic Details
Published in:	Diabetologia Vol. 54; no. 6; pp. 1407 - 1416
Main Authors:	Lee, A. S., Ghoreishi, M., Cheng, W. K., Chang, T.-Y. E., Zhang, Y. Q., Dutz, J. P.
Format:	Journal Article
Language:	English
Published:	Berlin/Heidelberg Springer-Verlag 01-06-2011 Springer Springer Nature B.V
Subjects:	Animals Antigens Autoimmune Diseases - immunology Autoimmune Diseases - pathology Autoimmune Diseases - physiopathology Biological and medical sciences Bone marrow Bone Marrow Cells - cytology CD4-Positive T-Lymphocytes - drug effects CD4-Positive T-Lymphocytes - metabolism CD4-Positive T-Lymphocytes - pathology CD40 Antigens - pharmacology CD8-Positive T-Lymphocytes - drug effects CD8-Positive T-Lymphocytes - metabolism CD8-Positive T-Lymphocytes - pathology Cytokines Cytokines - metabolism Cytotoxicity Dendritic cells Dendritic Cells - cytology Dendritic Cells - drug effects Dendritic Cells - metabolism Diabetes Diabetes Mellitus - immunology Diabetes Mellitus - pathology Diabetes Mellitus - physiopathology Diabetes. Impaired glucose tolerance Disease Models, Animal Endocrine pancreas. Apud cells (diseases) Endocrinopathies Etiopathogenesis. Screening. Investigations. Target tissue resistance Human Physiology Imidazoles - pharmacology Interferon-alpha - metabolism Internal Medicine Lymphatic system Lymphocytes Medical sciences Medicine Medicine & Public Health Membrane Glycoproteins - agonists Membrane Glycoproteins - antagonists & inhibitors Membrane Glycoproteins - genetics Membrane Glycoproteins - physiology Metabolic Diseases Mice Mice, Inbred NOD Mice, Transgenic Pathogens Phosphatase Quinolines - pharmacology T cell receptors Toll-Like Receptor 7 - agonists Toll-Like Receptor 7 - antagonists & inhibitors Toll-Like Receptor 7 - genetics Toll-Like Receptor 7 - physiology Transgenic animals Viral infections Canada United States > US CD40 agonist IFN-α T cell activation 8.3 NOD mice BMDC CD8 CL097 Autoimmune diabetes TLR7 IRS661 Endocrinopathy Autoimmunity Agonist Alpha interferon Diabetes mellitus Rodentia Toll like receptor Vertebrata Mammalia Mouse Animal T-Lymphocyte
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