Novel Autoantibodies in Idiopathic Small Fiber Neuropathy
Objective Small fiber neuropathy (SFN) is clinically and etiologically heterogeneous. Although autoimmunity has been postulated to be pathophysiologically important in SFN, few autoantibodies have been described. We aimed to identify autoantibodies associated with idiopathic SFN (iSFN) by a novel hi...
Saved in:
| Published in: | Annals of neurology Vol. 91; no. 1; pp. 66 - 77 |
|---|---|
| Main Authors: | , , , , , , , , , , , , , , , , , , , , |
| Format: | Journal Article |
| Language: | English |
| Published: |
Hoboken, USA
John Wiley & Sons, Inc
01-01-2022
Wiley Subscription Services, Inc |
| Subjects: | |
| Online Access: | Get full text |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| Abstract | Objective
Small fiber neuropathy (SFN) is clinically and etiologically heterogeneous. Although autoimmunity has been postulated to be pathophysiologically important in SFN, few autoantibodies have been described. We aimed to identify autoantibodies associated with idiopathic SFN (iSFN) by a novel high‐throughput protein microarray platform that captures autoantibodies expressed in the native conformational state.
Methods
Sera from 58 SFN patients and 20 age‐ and gender‐matched healthy controls (HCs) were screened against >1,600 immune‐related antigens. Fluorescent unit readout and postassay imaging were performed, followed by composite data normalization and protein fold change (pFC) analysis. Analysis of an independent validation cohort of 33 SFN patients against the same 20 HCs was conducted to identify reproducible proteins in both cohorts.
Results
Nine autoantibodies were screened with statistical significance and pFC criteria in both cohorts, with at least 50% change in serum levels. Three proteins showed consistently high fold changes in main and validation cohorts: MX1 (FC = 2.99 and 3.07, respectively, p = 0.003, q = 0.076), DBNL (FC = 2.11 and 2.16, respectively, p = 0.009, q < 0.003), and KRT8 (FC = 1.65 and 1.70, respectively, p = 0.043, q < 0.003). Further subgroup analysis into iSFN and SFN by secondary causes (secondary SFN) in the main cohort showed that MX1 is higher in iSFN compared to secondary SFN (FC = 1.61 vs 0.106, p = 0.009).
Interpretation
Novel autoantibodies MX1, DBNL, and KRT8 are found in iSFN. MX1 may allow diagnostic subtyping of iSFN patients. ANN NEUROL 2022;91:66–77 |
|---|---|
| AbstractList | OBJECTIVESmall fiber neuropathy (SFN) is clinically and etiologically heterogeneous. Although autoimmunity has been postulated to be pathophysiologically important in SFN, few autoantibodies have been described. We aimed to identify autoantibodies associated with idiopathic SFN (iSFN) by a novel high-throughput protein microarray platform that captures autoantibodies expressed in the native conformational state. METHODSSera from 58 SFN patients and 20 age- and gender-matched healthy controls (HCs) were screened against >1,600 immune-related antigens. Fluorescent unit readout and postassay imaging were performed, followed by composite data normalization and protein fold change (pFC) analysis. Analysis of an independent validation cohort of 33 SFN patients against the same 20 HCs was conducted to identify reproducible proteins in both cohorts. RESULTSNine autoantibodies were screened with statistical significance and pFC criteria in both cohorts, with at least 50% change in serum levels. Three proteins showed consistently high fold changes in main and validation cohorts: MX1 (FC = 2.99 and 3.07, respectively, p = 0.003, q = 0.076), DBNL (FC = 2.11 and 2.16, respectively, p = 0.009, q < 0.003), and KRT8 (FC = 1.65 and 1.70, respectively, p = 0.043, q < 0.003). Further subgroup analysis into iSFN and SFN by secondary causes (secondary SFN) in the main cohort showed that MX1 is higher in iSFN compared to secondary SFN (FC = 1.61 vs 0.106, p = 0.009). INTERPRETATIONNovel autoantibodies MX1, DBNL, and KRT8 are found in iSFN. MX1 may allow diagnostic subtyping of iSFN patients. ANN NEUROL 2022;91:66-77. ObjectiveSmall fiber neuropathy (SFN) is clinically and etiologically heterogeneous. Although autoimmunity has been postulated to be pathophysiologically important in SFN, few autoantibodies have been described. We aimed to identify autoantibodies associated with idiopathic SFN (iSFN) by a novel high‐throughput protein microarray platform that captures autoantibodies expressed in the native conformational state.MethodsSera from 58 SFN patients and 20 age‐ and gender‐matched healthy controls (HCs) were screened against >1,600 immune‐related antigens. Fluorescent unit readout and postassay imaging were performed, followed by composite data normalization and protein fold change (pFC) analysis. Analysis of an independent validation cohort of 33 SFN patients against the same 20 HCs was conducted to identify reproducible proteins in both cohorts.ResultsNine autoantibodies were screened with statistical significance and pFC criteria in both cohorts, with at least 50% change in serum levels. Three proteins showed consistently high fold changes in main and validation cohorts: MX1 (FC = 2.99 and 3.07, respectively, p = 0.003, q = 0.076), DBNL (FC = 2.11 and 2.16, respectively, p = 0.009, q < 0.003), and KRT8 (FC = 1.65 and 1.70, respectively, p = 0.043, q < 0.003). Further subgroup analysis into iSFN and SFN by secondary causes (secondary SFN) in the main cohort showed that MX1 is higher in iSFN compared to secondary SFN (FC = 1.61 vs 0.106, p = 0.009).InterpretationNovel autoantibodies MX1, DBNL, and KRT8 are found in iSFN. MX1 may allow diagnostic subtyping of iSFN patients. ANN NEUROL 2022;91:66–77 Objective Small fiber neuropathy (SFN) is clinically and etiologically heterogeneous. Although autoimmunity has been postulated to be pathophysiologically important in SFN, few autoantibodies have been described. We aimed to identify autoantibodies associated with idiopathic SFN (iSFN) by a novel high‐throughput protein microarray platform that captures autoantibodies expressed in the native conformational state. Methods Sera from 58 SFN patients and 20 age‐ and gender‐matched healthy controls (HCs) were screened against >1,600 immune‐related antigens. Fluorescent unit readout and postassay imaging were performed, followed by composite data normalization and protein fold change (pFC) analysis. Analysis of an independent validation cohort of 33 SFN patients against the same 20 HCs was conducted to identify reproducible proteins in both cohorts. Results Nine autoantibodies were screened with statistical significance and pFC criteria in both cohorts, with at least 50% change in serum levels. Three proteins showed consistently high fold changes in main and validation cohorts: MX1 (FC = 2.99 and 3.07, respectively, p = 0.003, q = 0.076), DBNL (FC = 2.11 and 2.16, respectively, p = 0.009, q < 0.003), and KRT8 (FC = 1.65 and 1.70, respectively, p = 0.043, q < 0.003). Further subgroup analysis into iSFN and SFN by secondary causes (secondary SFN) in the main cohort showed that MX1 is higher in iSFN compared to secondary SFN (FC = 1.61 vs 0.106, p = 0.009). Interpretation Novel autoantibodies MX1, DBNL, and KRT8 are found in iSFN. MX1 may allow diagnostic subtyping of iSFN patients. ANN NEUROL 2022;91:66–77 Small fiber neuropathy (SFN) is clinically and etiologically heterogeneous. Although autoimmunity has been postulated to be pathophysiologically important in SFN, few autoantibodies have been described. We aimed to identify autoantibodies associated with idiopathic SFN (iSFN) by a novel high-throughput protein microarray platform that captures autoantibodies expressed in the native conformational state. Sera from 58 SFN patients and 20 age- and gender-matched healthy controls (HCs) were screened against >1,600 immune-related antigens. Fluorescent unit readout and postassay imaging were performed, followed by composite data normalization and protein fold change (pFC) analysis. Analysis of an independent validation cohort of 33 SFN patients against the same 20 HCs was conducted to identify reproducible proteins in both cohorts. Nine autoantibodies were screened with statistical significance and pFC criteria in both cohorts, with at least 50% change in serum levels. Three proteins showed consistently high fold changes in main and validation cohorts: MX1 (FC = 2.99 and 3.07, respectively, p = 0.003, q = 0.076), DBNL (FC = 2.11 and 2.16, respectively, p = 0.009, q < 0.003), and KRT8 (FC = 1.65 and 1.70, respectively, p = 0.043, q < 0.003). Further subgroup analysis into iSFN and SFN by secondary causes (secondary SFN) in the main cohort showed that MX1 is higher in iSFN compared to secondary SFN (FC = 1.61 vs 0.106, p = 0.009). Novel autoantibodies MX1, DBNL, and KRT8 are found in iSFN. MX1 may allow diagnostic subtyping of iSFN patients. ANN NEUROL 2022;91:66-77. |
| Author | Tan, Chi Hsien Rutt, Nurul H. Tan, Ti Myen Chan, Amanda C. Y. Hung, Jennifer H. M. Vijayan, Joy Chandra, Bharatendu Mak, Anselm Wilder‐Smith, Einar Sharma, Vijay K. Ng, Kay W. P. Ismail, Nur Hafiza Ng, Alison Y. Y. Lai, Poh San Wong, Hiu Yi Chong, Yao Feng Choi, Hyungwon Schwarz, Herbert Teoh, Hock Luen Chan, Yee Cheun Ong, Jonathan J. Y. |
| AuthorAffiliation | 9 Department of Neurology Inselspital Bern, University of Bern Bern Switzerland 10 Division of Rheumatology University Medicine Cluster, National University Health System Singapore 5 Hong Kong Center for Neurodegenerative Diseases, Hong Kong Science Park Pak Shek Kok China 1 Division of Neurology, Department of Medicine National University Health System Singapore 3 Department of Physiology, Yong Loo Lin School of Medicine National University of Singapore Singapore 4 Division of Life Science, State Key Laboratory of Molecular Neuroscience Hong Kong University of Science and Technology Clear Water Bay Hong Kong 2 Department of Medicine, Yong Loo Lin School of Medicine National University of Singapore Singapore 8 Sengenics Singapore 6 Department of Pediatrics, Yong Loo Lin School of Medicine National University of Singapore Singapore 7 Division of Medical Genetics University of Iowa Iowa City IA USA |
| AuthorAffiliation_xml | – name: 6 Department of Pediatrics, Yong Loo Lin School of Medicine National University of Singapore Singapore – name: 5 Hong Kong Center for Neurodegenerative Diseases, Hong Kong Science Park Pak Shek Kok China – name: 2 Department of Medicine, Yong Loo Lin School of Medicine National University of Singapore Singapore – name: 10 Division of Rheumatology University Medicine Cluster, National University Health System Singapore – name: 4 Division of Life Science, State Key Laboratory of Molecular Neuroscience Hong Kong University of Science and Technology Clear Water Bay Hong Kong – name: 3 Department of Physiology, Yong Loo Lin School of Medicine National University of Singapore Singapore – name: 7 Division of Medical Genetics University of Iowa Iowa City IA USA – name: 9 Department of Neurology Inselspital Bern, University of Bern Bern Switzerland – name: 1 Division of Neurology, Department of Medicine National University Health System Singapore – name: 8 Sengenics Singapore |
| Author_xml | – sequence: 1 givenname: Amanda C. Y. orcidid: 0000-0002-2950-3707 surname: Chan fullname: Chan, Amanda C. Y. email: acychan@nus.edu.sg organization: National University of Singapore – sequence: 2 givenname: Hiu Yi surname: Wong fullname: Wong, Hiu Yi organization: Hong Kong Center for Neurodegenerative Diseases, Hong Kong Science Park – sequence: 3 givenname: Yao Feng surname: Chong fullname: Chong, Yao Feng organization: National University of Singapore – sequence: 4 givenname: Poh San orcidid: 0000-0003-3352-2000 surname: Lai fullname: Lai, Poh San organization: National University of Singapore – sequence: 5 givenname: Hock Luen surname: Teoh fullname: Teoh, Hock Luen organization: National University of Singapore – sequence: 6 givenname: Alison Y. Y. orcidid: 0000-0003-0735-8593 surname: Ng fullname: Ng, Alison Y. Y. organization: National University Health System – sequence: 7 givenname: Jennifer H. M. surname: Hung fullname: Hung, Jennifer H. M. organization: National University of Singapore – sequence: 8 givenname: Yee Cheun surname: Chan fullname: Chan, Yee Cheun organization: National University of Singapore – sequence: 9 givenname: Kay W. P. surname: Ng fullname: Ng, Kay W. P. organization: National University of Singapore – sequence: 10 givenname: Joy surname: Vijayan fullname: Vijayan, Joy organization: National University of Singapore – sequence: 11 givenname: Jonathan J. Y. surname: Ong fullname: Ong, Jonathan J. Y. organization: National University of Singapore – sequence: 12 givenname: Bharatendu surname: Chandra fullname: Chandra, Bharatendu organization: University of Iowa – sequence: 13 givenname: Chi Hsien surname: Tan fullname: Tan, Chi Hsien organization: National University of Singapore – sequence: 14 givenname: Nurul H. surname: Rutt fullname: Rutt, Nurul H. organization: Sengenics – sequence: 15 givenname: Ti Myen surname: Tan fullname: Tan, Ti Myen organization: Sengenics – sequence: 16 givenname: Nur Hafiza surname: Ismail fullname: Ismail, Nur Hafiza organization: Sengenics – sequence: 17 givenname: Einar surname: Wilder‐Smith fullname: Wilder‐Smith, Einar organization: Inselspital Bern, University of Bern – sequence: 18 givenname: Herbert surname: Schwarz fullname: Schwarz, Herbert organization: National University of Singapore – sequence: 19 givenname: Hyungwon surname: Choi fullname: Choi, Hyungwon organization: National University of Singapore – sequence: 20 givenname: Vijay K. surname: Sharma fullname: Sharma, Vijay K. organization: National University of Singapore – sequence: 21 givenname: Anselm orcidid: 0000-0002-4688-7829 surname: Mak fullname: Mak, Anselm organization: University Medicine Cluster, National University Health System |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/34761434$$D View this record in MEDLINE/PubMed |
| BookMark | eNp1kctKxDAUhoMoOl4WvoAU3OiimpOkuWyEQbyBjAt1HdI2o5FOMiatMm9vdFRUcBU4-fj4z_k30aoP3iK0C_gIMCbHxpsjwgmXK2gEFYVSEqZW0QhTzsoKKNtAmyk9YYwVB7yONigTHBhlI6Qm4cV2xXjog_G9q0PrbCqcL65aF-amf3RNcTszXVecu9rGYmKH-DFfbKO1qemS3fl8t9D9-dnd6WV5fXNxdTq-LhvGqCyFMi0XLVgwjaHUKCwVx5RaBVDLFoQgShDWWgMKi3oqsAQjJKswow2bcrqFTpbe-VDPbNtY30fT6Xl0MxMXOhinf_9496gfwotWNN8G4yw4-BTE8DzY1OuZS43tOuNtGJImleKsEjlTRvf_oE9hiD6vpwkHkFJSSTJ1uKSaGFKKdvodBrB-L0TnQvRHIZnd-5n-m_xqIAPHS-DVdXbxv0mPJ-Ol8g0k2ZTI |
| CitedBy_id | crossref_primary_10_1016_j_jdcr_2024_03_013 crossref_primary_10_1136_jnnp_2021_328489 crossref_primary_10_1016_j_autrev_2022_103230 crossref_primary_10_1016_j_autrev_2022_103231 crossref_primary_10_1007_s10286_022_00854_5 crossref_primary_10_37349_ent_2022_00033 crossref_primary_10_1002_mus_27800 crossref_primary_10_1097_WCO_0000000000001103 crossref_primary_10_1515_revneuro_2024_0027 crossref_primary_10_1002_mus_27752 crossref_primary_10_1097_j_pain_0000000000003260 crossref_primary_10_3389_fnmol_2023_1254854 crossref_primary_10_1212_NXI_0000000000200248 |
| Cites_doi | 10.1214/aos/1074290335 10.1074/jbc.M500391200 10.1074/jbc.M312659200 10.1080/14789450.2017.1347042 10.1016/j.jns.2009.10.006 10.1212/WNL.0000000000001559 10.1093/nar/gkaa1100 10.1038/s41598-019-55212-9 10.1002/mus.25738 10.1177/0961203320959696 10.1093/chromsci/bmw167 10.1002/mus.23891 10.1155/2020/7289194 10.1093/brain/awz333 10.3109/s10165-009-0180-2 10.1038/nrneurol.2017.84 10.1016/j.jns.2008.12.018 10.1002/mus.26748 10.1016/j.rmed.2010.09.015 10.1212/NXI.0000000000001028 10.1002/cem.785 10.1016/j.autrev.2011.05.012 10.1007/s00415-006-0147-6 10.1093/nar/gkh192 10.1016/j.rmed.2017.03.011 10.1002/cne.21351 10.1007/s00415-020-10033-z 10.1136/jnnp.2005.084533 10.1136/jnnp-2019-321849 10.1002/ana.25279 10.1097/CND.0000000000000154 10.1073/pnas.052430399 10.1002/mus.27340 10.2337/dc10-1303 10.1212/WNL.54.7.1448 10.1212/WNL.0000000000011919 10.1111/j.1529-8027.2010.00271.x 10.1177/1756285617744484 10.1128/JVI.78.8.4323-4329.2004 10.1093/bjaed/mkv034 10.1007/s10072-019-03871-x 10.1186/s13063-016-1450-x 10.1038/ng1106 |
| ContentType | Journal Article |
| Copyright | 2021 The Authors. published by Wiley Periodicals LLC on behalf of American Neurological Association. 2021 The Authors. Annals of Neurology published by Wiley Periodicals LLC on behalf of American Neurological Association. 2021. This article is published under http://creativecommons.org/licenses/by-nc/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. |
| Copyright_xml | – notice: 2021 The Authors. published by Wiley Periodicals LLC on behalf of American Neurological Association. – notice: 2021 The Authors. Annals of Neurology published by Wiley Periodicals LLC on behalf of American Neurological Association. – notice: 2021. This article is published under http://creativecommons.org/licenses/by-nc/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. |
| DBID | 24P WIN CGR CUY CVF ECM EIF NPM AAYXX CITATION 7TK 7U7 C1K K9. 7X8 5PM |
| DOI | 10.1002/ana.26268 |
| DatabaseName | Wiley Open Access Wiley Online Library Journals Medline MEDLINE MEDLINE (Ovid) MEDLINE MEDLINE PubMed CrossRef Neurosciences Abstracts Toxicology Abstracts Environmental Sciences and Pollution Management ProQuest Health & Medical Complete (Alumni) MEDLINE - Academic PubMed Central (Full Participant titles) |
| DatabaseTitle | MEDLINE Medline Complete MEDLINE with Full Text PubMed MEDLINE (Ovid) CrossRef ProQuest Health & Medical Complete (Alumni) Toxicology Abstracts Neurosciences Abstracts Environmental Sciences and Pollution Management MEDLINE - Academic |
| DatabaseTitleList | MEDLINE - Academic ProQuest Health & Medical Complete (Alumni) MEDLINE |
| Database_xml | – sequence: 1 dbid: ECM name: MEDLINE url: https://search.ebscohost.com/login.aspx?direct=true&db=cmedm&site=ehost-live sourceTypes: Index Database |
| DeliveryMethod | fulltext_linktorsrc |
| Discipline | Medicine |
| DocumentTitleAlternate | Antibodies in Idiopathic SFN |
| EISSN | 1531-8249 |
| EndPage | 77 |
| ExternalDocumentID | 10_1002_ana_26268 34761434 ANA26268 |
| Genre | article Research Support, Non-U.S. Gov't Journal Article |
| GroupedDBID | --- .3N .55 .GA .GJ .Y3 05W 0R~ 10A 1CY 1L6 1OB 1OC 1ZS 23M 24P 2QL 31~ 33P 3O- 3SF 3WU 4.4 4ZD 50Y 50Z 51W 51X 52M 52N 52O 52P 52R 52S 52T 52U 52V 52W 52X 53G 5GY 5VS 66C 6J9 6P2 6PF 702 7PT 8-0 8-1 8-3 8-4 8-5 8UM 930 A01 A03 AAEJM AAESR AAEVG AAHHS AANLZ AAONW AAQQT AASGY AAWTL AAXRX AAZKR ABCQN ABCUV ABEML ABIJN ABIVO ABJNI ABLJU ABOCM ABPVW ABQWH ABXGK ACAHQ ACBMB ACBWZ ACCFJ ACCZN ACGFO ACGFS ACGOF ACMXC ACPOU ACPRK ACRZS ACSCC ACXBN ACXQS ADBBV ADBTR ADEOM ADIZJ ADKYN ADMGS ADOZA ADXAS ADZMN ADZOD AEEZP AEGXH AEIGN AEIMD AENEX AEQDE AEUQT AEUYR AFAZI AFBPY AFFNX AFFPM AFGKR AFPWT AFRAH AFZJQ AHBTC AHMBA AI. AIACR AIAGR AITYG AIURR AIWBW AJBDE AJJEV ALAGY ALMA_UNASSIGNED_HOLDINGS ALUQN AMBMR AMYDB ASPBG ATUGU AVWKF AZBYB AZFZN AZVAB BAFTC BDRZF BFHJK BHBCM BMXJE BROTX BRXPI BY8 C45 CS3 D-6 D-7 D-E D-F DCZOG DPXWK DR1 DR2 DRFUL DRMAN DRSTM EBS EJD EMOBN F00 F01 F04 F5P F8P FEDTE FUBAC FYBCS G-S G.N GNP GODZA GOZPB GRPMH H.X HBH HF~ HGLYW HHY HHZ HVGLF HZ~ IX1 J0M J5H JPC KBYEO KD1 KQQ L7B LATKE LAW LC2 LC3 LEEKS LH4 LITHE LOXES LP6 LP7 LUTES LW6 LXL LXN LXY LYRES M6M MEWTI MK4 MRFUL MRMAN MRSTM MSFUL MSMAN MSSTM MXFUL MXMAN MXSTM N04 N05 N4W N9A NF~ NNB O66 O9- OHT OIG OVD P2P P2W P2X P2Z P4B P4D PALCI PQQKQ Q.- Q.N Q11 QB0 QRW R.K RIWAO RJQFR ROL RWD RWI RX1 SAMSI SJN SUPJJ TEORI UB1 V2E V8K V9Y VH1 W8V W99 WBKPD WH7 WHWMO WIB WIH WIJ WIK WIN WJL WOHZO WQJ WRC WUP WVDHM WXI WXSBR X7M XG1 XJT XPP XSW XV2 YOC YQJ ZGI ZRF ZRR ZXP ZZTAW ~IA ~WT ~X8 CGR CUY CVF ECM EIF NPM AAMNL AAYXX CITATION 7TK 7U7 C1K K9. 7X8 5PM |
| ID | FETCH-LOGICAL-c4438-79ad67d1e1aca33a90896033e911b8d17729724dea1907bf7081a7845043c4f63 |
| IEDL.DBID | 33P |
| ISSN | 0364-5134 |
| IngestDate | Tue Sep 17 21:11:32 EDT 2024 Sat Aug 17 03:06:42 EDT 2024 Thu Oct 10 22:10:04 EDT 2024 Thu Nov 21 23:49:01 EST 2024 Sat Sep 28 08:34:10 EDT 2024 Sat Aug 24 00:58:33 EDT 2024 |
| IsDoiOpenAccess | true |
| IsOpenAccess | true |
| IsPeerReviewed | true |
| IsScholarly | true |
| Issue | 1 |
| Language | English |
| License | Attribution-NonCommercial 2021 The Authors. Annals of Neurology published by Wiley Periodicals LLC on behalf of American Neurological Association. This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes. |
| LinkModel | DirectLink |
| MergedId | FETCHMERGED-LOGICAL-c4438-79ad67d1e1aca33a90896033e911b8d17729724dea1907bf7081a7845043c4f63 |
| Notes | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 Correction added on December 3, 2021, after first online publication: The affiliation for Einar Wilder‐Smith has been updated. |
| ORCID | 0000-0003-3352-2000 0000-0003-0735-8593 0000-0002-2950-3707 0000-0002-4688-7829 |
| OpenAccessLink | https://onlinelibrary.wiley.com/doi/abs/10.1002%2Fana.26268 |
| PMID | 34761434 |
| PQID | 2611888382 |
| PQPubID | 946345 |
| PageCount | 12 |
| ParticipantIDs | pubmedcentral_primary_oai_pubmedcentral_nih_gov_9300200 proquest_miscellaneous_2596457033 proquest_journals_2611888382 crossref_primary_10_1002_ana_26268 pubmed_primary_34761434 wiley_primary_10_1002_ana_26268_ANA26268 |
| PublicationCentury | 2000 |
| PublicationDate | January 2022 |
| PublicationDateYYYYMMDD | 2022-01-01 |
| PublicationDate_xml | – month: 01 year: 2022 text: January 2022 |
| PublicationDecade | 2020 |
| PublicationPlace | Hoboken, USA |
| PublicationPlace_xml | – name: Hoboken, USA – name: United States – name: Minneapolis |
| PublicationTitle | Annals of neurology |
| PublicationTitleAlternate | Ann Neurol |
| PublicationYear | 2022 |
| Publisher | John Wiley & Sons, Inc Wiley Subscription Services, Inc |
| Publisher_xml | – name: John Wiley & Sons, Inc – name: Wiley Subscription Services, Inc |
| References | 2010; 33 2021; 8 2019; 9 2007; 503 2013; 48 2021; 64 2010; 15 2015; 16 2006; 77 2020; 61 2002; 99 2006; 253 2003; 17 2018; 84 2020; 267 2016; 17 2021; 96 2012; 11 2009; 279 2003; 31 2003; 33 2019; 142 2011; 105 2004; 32 2005; 280 2019; 40 2004; 279 2020; 2020 2017; 14 2015; 84 2017; 55 2000; 54 2020; 91 2004; 78 2017; 13 2020; 49 2017; 18 2018; 11 2009; 19 2010; 290 2017; 126 2020; 29 2018; 57 e_1_2_8_28_1 e_1_2_8_29_1 e_1_2_8_24_1 e_1_2_8_25_1 e_1_2_8_26_1 e_1_2_8_27_1 e_1_2_8_3_1 e_1_2_8_2_1 e_1_2_8_5_1 e_1_2_8_4_1 e_1_2_8_7_1 e_1_2_8_6_1 e_1_2_8_9_1 e_1_2_8_8_1 e_1_2_8_20_1 e_1_2_8_43_1 e_1_2_8_21_1 e_1_2_8_42_1 e_1_2_8_22_1 e_1_2_8_23_1 e_1_2_8_44_1 e_1_2_8_41_1 e_1_2_8_40_1 e_1_2_8_17_1 e_1_2_8_18_1 e_1_2_8_39_1 e_1_2_8_19_1 e_1_2_8_13_1 e_1_2_8_36_1 e_1_2_8_14_1 e_1_2_8_35_1 e_1_2_8_15_1 e_1_2_8_38_1 e_1_2_8_16_1 e_1_2_8_37_1 e_1_2_8_32_1 e_1_2_8_10_1 e_1_2_8_31_1 e_1_2_8_11_1 e_1_2_8_34_1 e_1_2_8_12_1 e_1_2_8_33_1 e_1_2_8_30_1 |
| References_xml | – volume: 105 start-page: 101 year: 2011 end-page: 105 article-title: Efficacy of intravenous immunoglobulin for small fiber neuropathy associated with sarcoidosis publication-title: Respir Med – volume: 279 start-page: 57 year: 2009 end-page: 61 article-title: Intravenous immunoglobulin treatment for painful sensory neuropathy associated with Sjögren's syndrome publication-title: J Neurol Sci – volume: 77 start-page: 967 year: 2006 end-page: 969 article-title: Intravenous immunoglobulin treatment in painful sensory neuropathy without sensory ataxia associated with Sjögren's syndrome publication-title: J Neurol Neurosurg Psychiatry – volume: 280 start-page: 19393 year: 2005 end-page: 19400 article-title: MxA, a member of the dynamin superfamily, interacts with the ankyrin‐like repeat domain of TRPC publication-title: J Biol Chem – volume: 54 start-page: 1448 year: 2000 end-page: 1452 article-title: Antisulfatide antibodies in neuropathy: clinical and electrophysiologic correlates publication-title: Neurology – volume: 253 start-page: 1011 year: 2006 end-page: 1015 article-title: Comparison of a simple method for quantitation of intraepidermal nerve fibres with a standard image analysis method using hypothenar skin publication-title: J Neurol – volume: 503 start-page: 35 year: 2007 end-page: 46 article-title: Cellular subtype distribution and developmental regulation of TRPC channel members in the mouse dorsal root ganglion publication-title: J Comp Neurol – volume: 13 start-page: 533 year: 2017 end-page: 547 article-title: Autoantibodies in chronic inflammatory neuropathies: diagnostic and therapeutic implications publication-title: Nat Rev Neurol – volume: 91 start-page: 49 year: 2020 end-page: 57 article-title: Clinical characterisation of sensory neuropathy with anti‐FGFR3 autoantibodies publication-title: J Neurol Neurosurg Psychiatry – volume: 57 start-page: 320 year: 2018 end-page: 324 article-title: Acute painful autoimmune neuropathy: a variant of Guillain‐Barré syndrome publication-title: Muscle Nerve – volume: 290 start-page: 115 year: 2010 end-page: 122 article-title: Differential gene expression in chronic inflammatory demyelinating polyneuropathy (CIDP) skin biopsies publication-title: J Neurol Sci – volume: 19 start-page: 437 year: 2009 end-page: 440 article-title: Extreme efficacy of intravenous immunoglobulin therapy for severe burning pain in a patient with small fiber neuropathy associated with primary Sjögren's syndrome publication-title: Mod Rheumatol – volume: 279 start-page: 15550 year: 2004 end-page: 15560 article-title: Recruitment of the actin‐binding protein HIP‐55 to the immunological synapse regulates T cell receptor signaling and endocytosis publication-title: J Biol Chem – volume: 96 start-page: e2534 year: 2021 end-page: e2545 article-title: Intravenous immunoglobulin therapy in patients with painful idiopathic small fiber neuropathy publication-title: Neurology – volume: 126 start-page: 135 year: 2017 end-page: 138 article-title: Sarcoidosis‐associated small fiber neuropathy in a large cohort: clinical aspects and response to IVIG and anti‐TNF alpha treatment publication-title: Respir Med – volume: 17 start-page: 330 year: 2016 article-title: Intravenous immunoglobulin therapy for small fiber neuropathy: study protocol for a randomized controlled trial publication-title: Trials – volume: 9 year: 2019 article-title: Differential regulation of TRP channel gene and protein expression by intervertebral disc degeneration and back pain publication-title: Sci Rep – volume: 32 start-page: 643 year: 2004 end-page: 652 article-title: Nuclear MxA proteins form a complex with influenza virus NP and inhibit the transcription of the engineered influenza virus genome publication-title: Nucleic Acids Res – volume: 48 start-page: 883 year: 2013 end-page: 888 article-title: Contribution of QSART to the diagnosis of small fiber neuropathy publication-title: Muscle Nerve – volume: 14 start-page: 627 year: 2017 end-page: 641 article-title: Advances in the development of human protein microarrays publication-title: Expert Rev Proteomics – volume: 55 start-page: 182 year: 2017 end-page: 196 article-title: Proteomics: technologies and their applications publication-title: J Chromatogr Sci – volume: 11 year: 2018 article-title: IVIg for apparently autoimmune small‐fiber polyneuropathy: first analysis of efficacy and safety publication-title: Ther Adv Neurol Disord – volume: 18 start-page: 125 year: 2017 end-page: 131 article-title: Diagnostic criteria for small fiber neuropathy publication-title: J Clin Neuromuscul Dis – volume: 33 start-page: 2285 year: 2010 end-page: 2293 article-title: Diabetic neuropathies: update on definitions, diagnostic criteria, estimation of severity, and treatments publication-title: Diabetes Care – volume: 49 start-page: D480 year: 2020 end-page: D489 article-title: UniProt: the universal protein knowledgebase in 2021 publication-title: Nucleic Acids Res – volume: 78 start-page: 4323 year: 2004 end-page: 4329 article-title: Human MxA protein inhibits the replication of Crimean‐Congo hemorrhagic fever virus publication-title: J Virol – volume: 99 start-page: 3153 year: 2002 end-page: 3158 article-title: Antivirally active MxA protein sequesters La Crosse virus nucleocapsid protein into perinuclear complexes publication-title: Proc Natl Acad Sci U S A – volume: 29 start-page: 1948 year: 2020 end-page: 1954 article-title: Detection of putative autoantibodies in systemic lupus erythematous using a novel native‐conformation protein microarray platform publication-title: Lupus – volume: 17 start-page: 166 year: 2003 end-page: 173 article-title: Partial least squares for discrimination publication-title: J Chemomet – volume: 40 start-page: 1343 year: 2019 end-page: 1350 article-title: Small‐fiber neuropathy definition, diagnosis, and treatment publication-title: Neurol Sci – volume: 267 start-page: 3499 year: 2020 end-page: 3507 article-title: Long‐term efficacy of immunoglobulins in small fiber neuropathy related to Sjögren's syndrome publication-title: J Neurol – volume: 84 start-page: e146 year: 2015 end-page: e152 article-title: Clinical reasoning: burning hands and feet publication-title: Neurology – volume: 84 start-page: 208 year: 2018 end-page: 224 article-title: A novel autoantibody against plexin D1 in patients with neuropathic pain publication-title: Ann Neurol – volume: 8 year: 2021 article-title: Antiplexin D1 antibodies relate to small fiber neuropathy and induce neuropathic pain in animals publication-title: Neurol Neuroimmunol Neuroinflam – volume: 15 start-page: 202 year: 2010 end-page: 207 article-title: Intraepidermal nerve fiber density at the distal leg: a worldwide normative reference study publication-title: J Peripher Nerv Syst – volume: 11 start-page: 196 year: 2012 end-page: 202 article-title: Autoimmune disorders affecting both the central and peripheral nervous system publication-title: Autoimmun Rev – volume: 31 start-page: 2013 year: 2003 end-page: 2035 article-title: The positive false discovery rate: a Bayesian interpretation and the q‐value publication-title: Ann Stat – volume: 61 start-page: 512 year: 2020 end-page: 515 article-title: Cryptogenic small‐fiber neuropathies: serum autoantibody binding to trisulfated heparan disaccharide and fibroblast growth factor receptor‐3 publication-title: Muscle Nerve – volume: 2020 year: 2020 article-title: Roles of TRP channels in neurological diseases publication-title: Oxid Med Cell Longev – volume: 33 start-page: 311 year: 2003 end-page: 323 article-title: Proteomics: the first decade and beyond publication-title: Nat Genet – volume: 16 start-page: 159 year: 2015 end-page: 161 article-title: Statistical analysis: sample size and power estimations publication-title: BJA Educat – volume: 142 start-page: 3728 year: 2019 end-page: 3736 article-title: Diagnostic criteria for small fibre neuropathy in clinical practice and research publication-title: Brain – volume: 64 start-page: 293 year: 2021 end-page: 300 article-title: Small fibre neuropathy: Swiss cohort characterization publication-title: Muscle Nerve – ident: e_1_2_8_27_1 doi: 10.1214/aos/1074290335 – ident: e_1_2_8_29_1 doi: 10.1074/jbc.M500391200 – ident: e_1_2_8_35_1 doi: 10.1074/jbc.M312659200 – ident: e_1_2_8_21_1 doi: 10.1080/14789450.2017.1347042 – ident: e_1_2_8_39_1 doi: 10.1016/j.jns.2009.10.006 – ident: e_1_2_8_23_1 doi: 10.1212/WNL.0000000000001559 – ident: e_1_2_8_28_1 doi: 10.1093/nar/gkaa1100 – ident: e_1_2_8_34_1 doi: 10.1038/s41598-019-55212-9 – ident: e_1_2_8_20_1 doi: 10.1002/mus.25738 – ident: e_1_2_8_16_1 doi: 10.1177/0961203320959696 – ident: e_1_2_8_15_1 doi: 10.1093/chromsci/bmw167 – ident: e_1_2_8_43_1 doi: 10.1002/mus.23891 – ident: e_1_2_8_38_1 doi: 10.1155/2020/7289194 – ident: e_1_2_8_44_1 doi: 10.1093/brain/awz333 – ident: e_1_2_8_7_1 doi: 10.3109/s10165-009-0180-2 – ident: e_1_2_8_40_1 doi: 10.1038/nrneurol.2017.84 – ident: e_1_2_8_8_1 doi: 10.1016/j.jns.2008.12.018 – ident: e_1_2_8_19_1 doi: 10.1002/mus.26748 – ident: e_1_2_8_10_1 doi: 10.1016/j.rmed.2010.09.015 – ident: e_1_2_8_37_1 doi: 10.1212/NXI.0000000000001028 – ident: e_1_2_8_26_1 doi: 10.1002/cem.785 – ident: e_1_2_8_13_1 doi: 10.1016/j.autrev.2011.05.012 – ident: e_1_2_8_25_1 doi: 10.1007/s00415-006-0147-6 – ident: e_1_2_8_32_1 doi: 10.1093/nar/gkh192 – ident: e_1_2_8_11_1 doi: 10.1016/j.rmed.2017.03.011 – ident: e_1_2_8_33_1 doi: 10.1002/cne.21351 – ident: e_1_2_8_6_1 doi: 10.1007/s00415-020-10033-z – ident: e_1_2_8_9_1 doi: 10.1136/jnnp.2005.084533 – ident: e_1_2_8_18_1 doi: 10.1136/jnnp-2019-321849 – ident: e_1_2_8_36_1 doi: 10.1002/ana.25279 – ident: e_1_2_8_42_1 doi: 10.1097/CND.0000000000000154 – ident: e_1_2_8_30_1 doi: 10.1073/pnas.052430399 – ident: e_1_2_8_2_1 doi: 10.1002/mus.27340 – ident: e_1_2_8_22_1 doi: 10.2337/dc10-1303 – ident: e_1_2_8_17_1 doi: 10.1212/WNL.54.7.1448 – ident: e_1_2_8_12_1 doi: 10.1212/WNL.0000000000011919 – ident: e_1_2_8_24_1 doi: 10.1111/j.1529-8027.2010.00271.x – ident: e_1_2_8_4_1 doi: 10.1177/1756285617744484 – ident: e_1_2_8_31_1 doi: 10.1128/JVI.78.8.4323-4329.2004 – ident: e_1_2_8_41_1 doi: 10.1093/bjaed/mkv034 – ident: e_1_2_8_3_1 doi: 10.1007/s10072-019-03871-x – ident: e_1_2_8_5_1 doi: 10.1186/s13063-016-1450-x – ident: e_1_2_8_14_1 doi: 10.1038/ng1106 |
| SSID | ssj0009610 |
| Score | 2.504452 |
| Snippet | Objective
Small fiber neuropathy (SFN) is clinically and etiologically heterogeneous. Although autoimmunity has been postulated to be pathophysiologically... Small fiber neuropathy (SFN) is clinically and etiologically heterogeneous. Although autoimmunity has been postulated to be pathophysiologically important in... ObjectiveSmall fiber neuropathy (SFN) is clinically and etiologically heterogeneous. Although autoimmunity has been postulated to be pathophysiologically... OBJECTIVESmall fiber neuropathy (SFN) is clinically and etiologically heterogeneous. Although autoimmunity has been postulated to be pathophysiologically... |
| SourceID | pubmedcentral proquest crossref pubmed wiley |
| SourceType | Open Access Repository Aggregation Database Index Database Publisher |
| StartPage | 66 |
| SubjectTerms | Adult Aged Antigens Autoantibodies Autoantibodies - blood Autoantibodies - immunology Autoantigens - immunology Autoimmunity Cohort Studies Etiology Female Fluorescence Humans Keratin-8 - immunology Male Microfilament Proteins - immunology Middle Aged Myxovirus Resistance Proteins - immunology Neuropathy Protein arrays Protein folding Proteins Serum levels Small Fiber Neuropathy - blood Small Fiber Neuropathy - immunology src Homology Domains - immunology Subgroups |
| Title | Novel Autoantibodies in Idiopathic Small Fiber Neuropathy |
| URI | https://onlinelibrary.wiley.com/doi/abs/10.1002%2Fana.26268 https://www.ncbi.nlm.nih.gov/pubmed/34761434 https://www.proquest.com/docview/2611888382 https://search.proquest.com/docview/2596457033 https://pubmed.ncbi.nlm.nih.gov/PMC9300200 |
| Volume | 91 |
| hasFullText | 1 |
| inHoldings | 1 |
| isFullTextHit | |
| isPrint | |
| link | http://sdu.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwpZ3PS8MwFMcfuoN48feP6pQqHrzUrU3atHga6pgHhzAFbyVtUizMVtwm-N_7Xrp1jiEI3tompeHl1zd5eZ8CXOCsIYIMl6nKDyIKyYmcBFWBw8NUJCz0lWfYnb2B6L-Et3eEybmexcJUfIh6w416hhmvqYPLZNSaQ0NlIa88lOMU6IurBBO-wR7nwN3AkAjIzeb4LuMzqlDba9VvLs5FSwJz-ZzkT_1qJqDu5r-KvgUbU91pd6qGsg0rutiBtYepZ30Xon75qTF9Mi7R1nlS0ulCOy_se5WX5rfFqT14k8Oh3aUzJraBetDzrz147t493fSc6W8VnJRzHN5EJFUglKtdmUrGJHn-gjZjGse9JFQu6W3hcaUligWRZAJVgxQhJ9ZZyrOA7UOjKAt9CDbx65XmwpOZ5JpnkYv3PoqwJFNJxn0LzmcGjt8rekZccZK9GI0QGyNY0JyZPp52oBGm4MonDFnoWXBWJ2PTJ3-GLHQ5wTx-FHAiiDELDqqaqr_CuEDhwbgFYqEO6wyE1V5MKfJXg9eOGGnotgWXpg5_L3jc6XfMxdHfsx7DukcBFGYTpwmN8cdEn8DqSE1OTfv9BtwF7w8 |
| link.rule.ids | 230,315,782,786,887,1408,27933,27934,46064,46488 |
| linkProvider | Wiley-Blackwell |
| linkToHtml | http://sdu.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwpZ1LS8QwEMcHXUG9-H5UV63iwUt126RNCl4WdVlRF0EFbyVtUlzQVtQV_PbOpLvVRQTBW9tJaZi8_skkvwLs46ghohynqTqMYjqSE3spqgKPy0ykTIY6sOzO7o3o3cvTM8LkHI_OwlR8iHrBjVqG7a-pgdOC9NEXNVQV6jBAPS4nYYpHWBHpAAe7_kLuRpZFQIE2L_QZH3GFWsFR_er4aPRDYv7cKfldwdohqDP_v8wvwNxQerrtqq4swoQplmD6ahhcX4a4V74btA_eSnR3Py1pg6HbL9xz3S_tn4sz9-ZJPT66Hdpm4lquBz3_WIG7ztntSdcb_lnByzjHHk7ESkdC-8ZXmWJMUfAvajFmsOtLpfZJcouAa6NQL4g0FygclJCccGcZzyO2Co2iLMw6uISw14aLQOWKG57HPt6HqMPSXKc5Dx3YG3k4ea4AGkmFSg4SdEJineBAc-T7ZNiGXtGCkx8pmQwc2K3NWPsppKEKUw4wTRhHnCBizIG1qqjqrzAuUHsw7oAYK8Q6AZG1xy1F_8EStmNGMrrlwIEtxN8znrR7bXux8fekOzDTvb26TC7PexebMBvQeQq7ptOExtvLwGzB5KsebNvK_An7lvM3 |
| linkToPdf | http://sdu.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwpZ1bS8MwFMcPXmD44v1Sr1V88KW6NmmT4tPQDUUdgyn4VtImxYG2ok7w23tOulWHCIJvbU9Kw8ntn5zkV4BDHDVElOM0VYdRTEdyYi9FVeBxmYmUyVAHlt150Rfde3neJkzO6fgsTMWHqBfcqGXY_poa-LPOT76goapQxwHKcTkNsxxlOIHzGet9EXcjiyKgOJsX-oyPsULN4KR-dXIw-qEwf26U_C5g7QjUWfhX3hdhfiQ83VZVU5ZgyhTL0LgZhdZXIO6W7wbtw7cSnT1IS9pe6A4K91IPSvvf4sztP6nHR7dDm0xcS_Wg5x-rcNdp355deKP_KngZ59i_iVjpSGjf-CpTjCkK_UVNxgx2fKnUPgluEXBtFKoFkeYCZYMSkhPsLON5xNZgpigLswEuAey14SJQueKG57GP9yGqsDTXac5DBw7GDk6eK3xGUoGSgwSdkFgnOLA9dn0yakGvaMGpj5RMBg7s12as-xTQUIUph5gmjCNOCDHmwHpVUvVXGBeoPBh3QEyUYZ2AuNqTlmLwYPnaMSMR3XTgyJbh7xlPWt2Wvdj8e9I9aPTOO8n1ZfdqC-YCOkxhF3S2YebtZWh2YPpVD3dtVf4EDzLx3Q |
| openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Novel+Autoantibodies+in+Idiopathic+Small+Fiber+Neuropathy&rft.jtitle=Annals+of+neurology&rft.au=Chan%2C+Amanda+C.+Y.&rft.au=Wong%2C+Hiu+Yi&rft.au=Chong%2C+Yao+Feng&rft.au=Lai%2C+Poh+San&rft.date=2022-01-01&rft.pub=John+Wiley+%26+Sons%2C+Inc&rft.issn=0364-5134&rft.eissn=1531-8249&rft.volume=91&rft.issue=1&rft.spage=66&rft.epage=77&rft_id=info:doi/10.1002%2Fana.26268&rft.externalDBID=10.1002%252Fana.26268&rft.externalDocID=ANA26268 |
| thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=0364-5134&client=summon |
| thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=0364-5134&client=summon |
| thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=0364-5134&client=summon |