Whole blood interleukin‐2 release test to detect and characterize rare circulating gluten‐specific T cell responses in coeliac disease

Summary Whole blood cytokine release assays (CRA) assessing cellular immunity to gluten could simplify the diagnosis and monitoring of coeliac disease (CD). We aimed to determine the effectiveness of electrochemiluminescence CRA to detect responses to immunodominant gliadin peptides. HLA‐DQ2·5+ CD a...

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Bibliographic Details
Published in:	Clinical and experimental immunology Vol. 204; no. 3; pp. 321 - 334
Main Authors:	Anderson, R. P., Goel, G., Hardy, M. Y., Russell, A, K., Wang, S., Szymczak, E., Zhang, R., Goldstein, K. E., Neff, K., Truitt, K. E., Williams, L. J., Dzuris, J. L., Tye‐Din, J. A.
Format:	Journal Article
Language:	English
Published:	England Oxford University Press 01-06-2021 John Wiley and Sons Inc
Subjects:	Blood CCL3 protein Celiac disease Cell-mediated immunity Chemokines coeliac disease CXCL10 protein cytokine release assay Cytokines Diagnosis Enzyme-linked immunosorbent assay Epitopes Gliadin Gluten Guanylate cyclase Histocompatibility antigen HLA IL‐2 Immunodominance Inflammation Interferon Ligands Lymphocytes T Macrophage inflammatory protein Macrophage inflammatory protein 1 Original Peptides Sensitivity analysis T cells Tumor necrosis factor coeliac disease diagnosis IL-2 cytokine release assay cytokines T cells
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