Human platelets express endothelial protein C receptor, which can be utilized to enhance localization of factor VIIa activity

Essentials Factor VIIa binds activated platelets to promote hemostasis in hemophilia patients with inhibitors. The interactions and sites responsible for platelet‐FVIIa binding are not fully understood. Endothelial cell protein C receptor (EPCR) is expressed on activated human platelets. EPCR bindin...

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Bibliographic Details
Published in:	Journal of thrombosis and haemostasis Vol. 16; no. 9; pp. 1817 - 1829
Main Authors:	Fager, A. M., Machlus, K. R., Ezban, M., Hoffman, M.
Format:	Journal Article
Language:	English
Published:	England Elsevier Limited 01-09-2018
Subjects:	Adult Binding, Competitive Blood Platelets - metabolism Carrier Proteins - pharmacology coagulation Coagulation factor VIIa Crotalid Venoms - pharmacology Endothelial cells Endothelial Cells - metabolism endothelial protein c receptor Endothelial Protein C Receptor - biosynthesis Endothelial Protein C Receptor - blood factor VIIa Factor VIIa - genetics Factor VIIa - metabolism Factor Xa - biosynthesis Flow cytometry Hemophilia Hemostasis Humans Immunofluorescence Immunoprecipitation Lectins, C-Type Lipid composition Localization Mass spectroscopy Peptides - pharmacology Platelet Activation Platelets Protein Binding Protein C Protein C - metabolism Proteins Thrombin Tissue factor hemophilia hemostasis endothelial protein c receptor factor VIIa coagulation
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