WEDGE: an anticoagulant thrombin mutant produced by autoactivation

Summary Background The production of therapeutically relevant proteases typically involves activation of a zymogen precursor by external enzymes, which may raise regulatory issues about availability and purity. Recent studies of thrombin precursors have shown how to engineer constructs that spontane...

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Bibliographic Details
Published in:	Journal of thrombosis and haemostasis Vol. 13; no. 1; pp. 111 - 114
Main Authors:	Wood, D. C., Pelc, L. A., Pozzi, N., Wallisch, M., Verbout, N. G., Tucker, E. I., Gruber, A., Di Cera, E.
Format:	Journal Article
Language:	English
Published:	England Elsevier Limited 01-01-2015
Subjects:	Amino Acid Substitution Animals anticoagulants Anticoagulants - administration & dosage Anticoagulants - metabolism Blood Coagulation - drug effects blood coagulation factors Catalysis Enzyme Activation Injections, Intravenous Mutation Papio Partial Thromboplastin Time protein engineering Protein Engineering - methods Prothrombin - administration & dosage Prothrombin - biosynthesis Prothrombin - genetics Recombinant Proteins - biosynthesis thrombin Thrombin - administration & dosage Thrombin - biosynthesis Thrombin - genetics zymogens blood coagulation factors anticoagulants protein engineering zymogens thrombin
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