Increased tau phosphorylation follows impeded dopamine clearance in a P301L and novel P301L/COMT‐deleted (DM) tau mouse model

In Alzheimer's disease, the phosphorylation of tau is a critical event preceding the formation of neurofibrillary tangles. Previous work exploring the impact of a dopamine blocking antipsychotic on tau phosphorylation in a tau transgenic model suggested that extracellular dopamine may play a re...

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Bibliographic Details
Published in:	Journal of neurochemistry Vol. 148; no. 1; pp. 127 - 135
Main Authors:	Koppel, Jeremy, Jimenez, Heidy, Adrien, Leslie, H. Chang, Eric, Malhotra, Anil K., Davies, Peter
Format:	Journal Article
Language:	English
Published:	England Blackwell Publishing Ltd 01-01-2019
Subjects:	Alzheimer's disease Animals Antipsychotics Brain Brain - metabolism Catechol Catechol O-methyltransferase Catechol O-Methyltransferase - deficiency Cortex (frontal) Dihydroxyphenylacetic acid Disease Models, Animal Dopamine Dopamine - metabolism Female Homovanillic acid Humans Kinases Male Metabolism Metabolites Methyltransferase Mice Mice, Knockout Mice, Transgenic Neostriatum Neurodegenerative diseases Neurofibrillary tangles Norepinephrine Phosphorylation Prefrontal cortex psychosis Reboxetine tau Tau protein tau Proteins - metabolism Tauopathies - metabolism tau Alzheimer's disease dopamine phosphorylation psychosis
Online Access:	Get full text
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