Hormonal Fluctuations during the Estrous Cycle Modulate Heme Oxygenase-1 Expression in the Uterus

Deletion of the heme oxygenase-1 (HO-1) (Hmox1) locus in mice results in intrauterine lethality. The expression of the heme catabolizing enzyme encoded by this gene, namely HO-1, is required to successfully support reproductive events. We have previously observed that HO-1 acts at several key events...

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Published in:	Frontiers in endocrinology (Lausanne) Vol. 5; p. 32
Main Authors:	Zenclussen, Maria Laura, Casalis, Pablo Ariel, Jensen, Federico, Woidacki, Katja, Zenclussen, Ana Claudia
Format:	Journal Article
Language:	English
Published:	Switzerland Frontiers Media S.A 13-03-2014
Subjects:	Endocrinology Estradiol Estrous Cycle Heme Oxygenase-1 Mouse Progesterone uterine cells uterine cells mouse estrous cycle heme oxygenase-1 progesterone estradiol
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Abstract	Deletion of the heme oxygenase-1 (HO-1) (Hmox1) locus in mice results in intrauterine lethality. The expression of the heme catabolizing enzyme encoded by this gene, namely HO-1, is required to successfully support reproductive events. We have previously observed that HO-1 acts at several key events in reproduction ensuring pregnancy. HO-1 defines ovulation, positively influences implantation and placentation, and ensures fetal growth and survival. Here, we embarked on a study aimed to determine whether hormonal changes during the estrous cycle in the mouse define HO-1 expression that may influence receptivity. We analyzed the serum levels of progesterone and estrogen by ELISA and HO-1 mRNA expression in uterus by real time RT-PCR at the metestrus, proestrus, estrus, and diestrus phases of the estrous cycle. Further, we studied the HO-1 protein expression by western blot upon hormone addition to cultured uterine AN3 cells. We observed that HO-1 variations in uterine tissue correlated to changes in hormonal levels at different phases of the estrus cycle. In vitro, HO-1 protein levels in AN3 cells augmented after the addition of physiological concentrations of progesterone and estradiol, which confirmed our in vivo observations. Our data suggest an important role for hormones in HO-1 regulation in uterus during receptivity, a process known to have a significant impact in receptivity and later on blastocyst implantation.
AbstractList	Deletion of the Heme Oxygenase-1 (Hmox1) locus in mice results in intrauterine lethality. The expression of the heme catabolyzing enzyme encoded by this gene, namely HO 1, is required to successfully support reproductive events. We have previously observed that HO-1 acts at several key events in reproduction ensuring pregnancy. HO-1 defines ovulation, positively influences implantation and placentation and ensures fetal growth and survival. Here, we embarked on a study aimed to determine whether hormonal changes during the estrous cycle in the mouse define HO-1 expression, thus influencing receptivity. We analyzed the serum levels of progesterone and estrogen by ELISA and HO-1 mRNA expression in uterus by real time RT-PCR at the metestrus, proestrus, estrus and diestrus phases of the estrous cycle. Further, we studied the HO-1 protein expression by Western Blot upon hormone addition to cultured uterine AN3 cells. We observed that HO-1 variations in uterine tissue correlated to changes in hormonal levels at different phases of the estrus cycle. In vitro, HO-1 protein levels in AN3 cells augmented after the addition of physiological concentrations of progesterone and estradiol, which confirmed our in vivo observations. Our data suggest an important role for hormones in HO-1 regulation in uterus that has a significant impact in receptivity and later on blastocyst implantation. Deletion of the heme oxygenase-1 (HO-1) ( Hmox1 ) locus in mice results in intrauterine lethality. The expression of the heme catabolizing enzyme encoded by this gene, namely HO-1, is required to successfully support reproductive events. We have previously observed that HO-1 acts at several key events in reproduction ensuring pregnancy. HO-1 defines ovulation, positively influences implantation and placentation, and ensures fetal growth and survival. Here, we embarked on a study aimed to determine whether hormonal changes during the estrous cycle in the mouse define HO-1 expression that may influence receptivity. We analyzed the serum levels of progesterone and estrogen by ELISA and HO-1 mRNA expression in uterus by real time RT-PCR at the metestrus, proestrus, estrus, and diestrus phases of the estrous cycle. Further, we studied the HO-1 protein expression by western blot upon hormone addition to cultured uterine AN3 cells. We observed that HO-1 variations in uterine tissue correlated to changes in hormonal levels at different phases of the estrus cycle. In vitro , HO-1 protein levels in AN3 cells augmented after the addition of physiological concentrations of progesterone and estradiol, which confirmed our in vivo observations. Our data suggest an important role for hormones in HO-1 regulation in uterus during receptivity, a process known to have a significant impact in receptivity and later on blastocyst implantation. Deletion of the heme oxygenase-1 (HO-1) (Hmox1) locus in mice results in intrauterine lethality. The expression of the heme catabolizing enzyme encoded by this gene, namely HO-1, is required to successfully support reproductive events. We have previously observed that HO-1 acts at several key events in reproduction ensuring pregnancy. HO-1 defines ovulation, positively influences implantation and placentation, and ensures fetal growth and survival. Here, we embarked on a study aimed to determine whether hormonal changes during the estrous cycle in the mouse define HO-1 expression that may influence receptivity. We analyzed the serum levels of progesterone and estrogen by ELISA and HO-1 mRNA expression in uterus by real time RT-PCR at the metestrus, proestrus, estrus, and diestrus phases of the estrous cycle. Further, we studied the HO-1 protein expression by western blot upon hormone addition to cultured uterine AN3 cells. We observed that HO-1 variations in uterine tissue correlated to changes in hormonal levels at different phases of the estrus cycle. In vitro, HO-1 protein levels in AN3 cells augmented after the addition of physiological concentrations of progesterone and estradiol, which confirmed our in vivo observations. Our data suggest an important role for hormones in HO-1 regulation in uterus during receptivity, a process known to have a significant impact in receptivity and later on blastocyst implantation.
Author	Woidacki, Katja Zenclussen, Maria Laura Jensen, Federico Casalis, Pablo Ariel Zenclussen, Ana Claudia
AuthorAffiliation	1 Department of Experimental Obstetrics and Gynecology, Medical Faculty, Otto-von-Guericke University , Magdeburg , Germany
AuthorAffiliation_xml	– name: 1 Department of Experimental Obstetrics and Gynecology, Medical Faculty, Otto-von-Guericke University , Magdeburg , Germany
Author_xml	– sequence: 1 givenname: Maria Laura surname: Zenclussen fullname: Zenclussen, Maria Laura organization: Department of Experimental Obstetrics and Gynecology, Medical Faculty, Otto-von-Guericke University , Magdeburg , Germany – sequence: 2 givenname: Pablo Ariel surname: Casalis fullname: Casalis, Pablo Ariel organization: Department of Experimental Obstetrics and Gynecology, Medical Faculty, Otto-von-Guericke University , Magdeburg , Germany – sequence: 3 givenname: Federico surname: Jensen fullname: Jensen, Federico organization: Department of Experimental Obstetrics and Gynecology, Medical Faculty, Otto-von-Guericke University , Magdeburg , Germany – sequence: 4 givenname: Katja surname: Woidacki fullname: Woidacki, Katja organization: Department of Experimental Obstetrics and Gynecology, Medical Faculty, Otto-von-Guericke University , Magdeburg , Germany – sequence: 5 givenname: Ana Claudia surname: Zenclussen fullname: Zenclussen, Ana Claudia organization: Department of Experimental Obstetrics and Gynecology, Medical Faculty, Otto-von-Guericke University , Magdeburg , Germany
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Cites_doi	10.1038/74680 10.1111/j.1600-0897.2011.01096.x 10.1016/j.jsbmb.2005.11.007 10.1186/2045-9912-2-4 10.1172/JCI927 10.1002/path.2946 10.1016/S0002-9440(10)62302-4 10.1146/annurev.pharmtox.010909.105600 10.1371/journal.pone.0042301 10.1073/pnas.61.2.748 10.1016/j.coph.2009.05.008 10.1095/biolreprod.103.026179 10.1016/j.jri.2005.10.001 10.1371/journal.pone.0048933 10.1071/RD11908 10.1016/0031-9384(83)90150-6 10.1016/j.molmed.2008.12.004 10.1016/j.fertnstert.2012.01.116 10.1016/S1471-4906(03)00181-9
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Keywords	uterine cells mouse estrous cycle heme oxygenase-1 progesterone estradiol
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Notes	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 Edited by: Wei Ge, The Chinese University of Hong Kong, China Reviewed by: Alice Wong, University of Hong Kong, China; Chun Peng, York University, Canada This article was submitted to Experimental Endocrinology, a section of the journal Frontiers in Endocrinology.
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Snippet	Deletion of the heme oxygenase-1 (HO-1) (Hmox1) locus in mice results in intrauterine lethality. The expression of the heme catabolizing enzyme encoded by this... Deletion of the heme oxygenase-1 (HO-1) ( Hmox1 ) locus in mice results in intrauterine lethality. The expression of the heme catabolizing enzyme encoded by... Deletion of the Heme Oxygenase-1 (Hmox1) locus in mice results in intrauterine lethality. The expression of the heme catabolyzing enzyme encoded by this gene,...
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SubjectTerms	Endocrinology Estradiol Estrous Cycle Heme Oxygenase-1 Mouse Progesterone uterine cells
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Title	Hormonal Fluctuations during the Estrous Cycle Modulate Heme Oxygenase-1 Expression in the Uterus
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