Selecting postoperative adjuvant systemic therapy for early stage breast cancer: A critical assessment of commercially available gene expression assays

• Published in: Journal of surgical oncology Vol. 115; no. 6; pp. 647 - 662
• Main Authors: Hyams, David M., Schuur, Eric, Angel Aristizabal, Javier, Bargallo Rocha, Juan Enrique, Cabello, Cesar, Elizalde, Roberto, García‐Estévez, Laura, Gomez, Henry L., Katz, Artur, Nuñez De Pierro, Aníbal
• Format: Journal Article
• Language: English
• Published: United States Wiley Subscription Services, Inc 01-05-2017; John Wiley and Sons Inc
• Subjects: adjuvant; biomarkers; Breast cancer; breast neoplasms; Breast Neoplasms - drug therapy; Breast Neoplasms - genetics; Breast Neoplasms - pathology; Breast Neoplasms - surgery; Cancer surgery; chemotherapy; Chemotherapy, Adjuvant; clinical decision‐making; Female; Gene expression; Gene Expression Profiling - methods; genomics risk; Humans; Postoperative period; prognosis; Randomized Controlled Trials as Topic; Reproducibility of Results; Review; tumor; genomics risk; adjuvant; biomarkers; breast neoplasms; tumor; clinical decision-making; chemotherapy; prognosis; gene expression
• ISSN: 0022-4790; 1096-9098
• DOI: 10.1002/jso.24561

Risk stratification of patients with early stage breast cancer may support adjuvant chemotherapy decision‐making. This review details the development and validation of six multi‐gene classifiers, each of which claims to provide useful prognostic and possibly predictive information for early stage breast cancer patients. A careful assessment is presented of each test's analytical validity, clinical validity, and clinical utility, as well as the quality of evidence supporting its use.