Glucocorticoid receptor-mediated suppression of the interleukin 2 gene expression through impairment of the cooperativity between nuclear factor of activated T cells and AP-1 enhancer elements

The immunosuppressant hormone dexamethasone (Dex) interferes with T cell-specific signals activating the enhancer sequences directing interleukin 2 (IL-2) transcription. We report that the Dex-dependent downregulation of 12-O-tetradecanoyl-phorbol-13-acetate (TPA) and calcium ionophore-induced activ...

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Bibliographic Details
Published in:	The Journal of experimental medicine Vol. 175; no. 3; pp. 637 - 646
Main Authors:	VACCA, A, FELLI, M. P, FARINA, A. R, MARTINOTTI, S, MARODER, M, SCREPANTI, I, MECO, D, PETRONGALI, E, FRATI, L, GILINO, A
Format:	Journal Article
Language:	English
Published:	New York, NY Rockefeller University Press 01-03-1992 The Rockefeller University Press
Subjects:	Analysis of the immune response. Humoral and cellular immunity Base Sequence Biological and medical sciences Dexamethasone - pharmacology Down-Regulation - drug effects Drug Synergism Enhancer Elements, Genetic - physiology Fundamental and applied biological sciences. Psychology Fundamental immunology Gene Expression - drug effects Immune Tolerance - drug effects Immunobiology Interleukin-1 - immunology Interleukin-2 - genetics Lymphocyte Activation Lymphocyte Cooperation Lymphokines, interleukins ( function, expression) Molecular Sequence Data Receptors, Glucocorticoid - physiology Regulatory factors and their cellular receptors T-Lymphocytes - immunology Transcription, Genetic Transcription Suppression Molecular interaction Activation Gene expression Glucocorticoid In vitro Plasmid Regulation(control) Interleukin 2 T-Lymphocyte Nuclear protein Biological receptor
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