Palmitic acid induces intestinal lipid metabolism disorder, endoplasmic reticulum stress and inflammation by affecting phosphatidylethanolamine content in large yellow croaker Larimichthys crocea
In the 21 st century, intestinal homeostatic imbalance has emerged as a growing health challenge worldwide. Accumulating evidence reveals that excessive intake of saturated fatty acid (SFA) induces intestinal homeostatic imbalance. However, the potential molecular mechanism is still unclear. In the...
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| Published in: | Frontiers in immunology Vol. 13; p. 984508 |
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| Main Authors: | , , , , , , , , , |
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| Abstract | In the 21
st
century, intestinal homeostatic imbalance has emerged as a growing health challenge worldwide. Accumulating evidence reveals that excessive intake of saturated fatty acid (SFA) induces intestinal homeostatic imbalance. However, the potential molecular mechanism is still unclear. In the present study, we found that palm oil or palmitic acid (PA) treatment disturbed lipid metabolism homeostasis and triggered endoplasmic reticulum (ER) stress and inflammation in the intestine or intestinal cells of large yellow croaker (
Larimichthys crocea
). Interestingly, PA treatment significantly decreased phosphatidylethanolamine (PE) content in the intestinal cells. PE supplementation decreased triglyceride content in the intestinal cells induced by PA treatment by inhibiting fatty acid uptake and lipogenesis. PE supplementation suppressed ER stress. Meanwhile, PE supplementation alleviated inflammatory response through p38 MAPK-p65 pathway, reducing the damage of intestinal cells caused by PA treatment to some extent. Our work revealed that intestinal homeostatic imbalance caused by PA treatment was partly due to the decrease of PE content. PE consumption might be a nutritional strategy to regulate intestinal homeostasis in fish and even human beings. |
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| AbstractList | In the 21st century, intestinal homeostatic imbalance has emerged as a growing health challenge worldwide. Accumulating evidence reveals that excessive intake of saturated fatty acid (SFA) induces intestinal homeostatic imbalance. However, the potential molecular mechanism is still unclear. In the present study, we found that palm oil or palmitic acid (PA) treatment disturbed lipid metabolism homeostasis and triggered endoplasmic reticulum (ER) stress and inflammation in the intestine or intestinal cells of large yellow croaker (Larimichthys crocea). Interestingly, PA treatment significantly decreased phosphatidylethanolamine (PE) content in the intestinal cells. PE supplementation decreased triglyceride content in the intestinal cells induced by PA treatment by inhibiting fatty acid uptake and lipogenesis. PE supplementation suppressed ER stress. Meanwhile, PE supplementation alleviated inflammatory response through p38 MAPK-p65 pathway, reducing the damage of intestinal cells caused by PA treatment to some extent. Our work revealed that intestinal homeostatic imbalance caused by PA treatment was partly due to the decrease of PE content. PE consumption might be a nutritional strategy to regulate intestinal homeostasis in fish and even human beings. In the 21 st century, intestinal homeostatic imbalance has emerged as a growing health challenge worldwide. Accumulating evidence reveals that excessive intake of saturated fatty acid (SFA) induces intestinal homeostatic imbalance. However, the potential molecular mechanism is still unclear. In the present study, we found that palm oil or palmitic acid (PA) treatment disturbed lipid metabolism homeostasis and triggered endoplasmic reticulum (ER) stress and inflammation in the intestine or intestinal cells of large yellow croaker ( Larimichthys crocea ). Interestingly, PA treatment significantly decreased phosphatidylethanolamine (PE) content in the intestinal cells. PE supplementation decreased triglyceride content in the intestinal cells induced by PA treatment by inhibiting fatty acid uptake and lipogenesis. PE supplementation suppressed ER stress. Meanwhile, PE supplementation alleviated inflammatory response through p38 MAPK-p65 pathway, reducing the damage of intestinal cells caused by PA treatment to some extent. Our work revealed that intestinal homeostatic imbalance caused by PA treatment was partly due to the decrease of PE content. PE consumption might be a nutritional strategy to regulate intestinal homeostasis in fish and even human beings. |
| Author | Liu, Yongtao Mai, Kangsen Ai, Qinghui Chen, Qiuchi Zhang, Lu Liu, Qiangde Cao, Xiufei Fang, Wei Xu, Dan Hao, Tingting |
| AuthorAffiliation | 3 Healthy Aquaculture Key Laboratory of Sichuan Province , Chengdu , China 2 Tongwei Co., Ltd. , Chengdu , China 4 Laboratory for Marine Fisheries Science and Food Production Processes, Qingdao National Laboratory for Marine Science and Technology , Qingdao , China 1 Key Laboratory of Aquaculture Nutrition and Feed (Ministry of Agriculture and Rural Affairs) and Key Laboratory of Mariculture (Ministry of Education), Ocean University of China , Qingdao , China |
| AuthorAffiliation_xml | – name: 4 Laboratory for Marine Fisheries Science and Food Production Processes, Qingdao National Laboratory for Marine Science and Technology , Qingdao , China – name: 3 Healthy Aquaculture Key Laboratory of Sichuan Province , Chengdu , China – name: 2 Tongwei Co., Ltd. , Chengdu , China – name: 1 Key Laboratory of Aquaculture Nutrition and Feed (Ministry of Agriculture and Rural Affairs) and Key Laboratory of Mariculture (Ministry of Education), Ocean University of China , Qingdao , China |
| Author_xml | – sequence: 1 givenname: Wei surname: Fang fullname: Fang, Wei – sequence: 2 givenname: Yongtao surname: Liu fullname: Liu, Yongtao – sequence: 3 givenname: Qiuchi surname: Chen fullname: Chen, Qiuchi – sequence: 4 givenname: Dan surname: Xu fullname: Xu, Dan – sequence: 5 givenname: Qiangde surname: Liu fullname: Liu, Qiangde – sequence: 6 givenname: Xiufei surname: Cao fullname: Cao, Xiufei – sequence: 7 givenname: Tingting surname: Hao fullname: Hao, Tingting – sequence: 8 givenname: Lu surname: Zhang fullname: Zhang, Lu – sequence: 9 givenname: Kangsen surname: Mai fullname: Mai, Kangsen – sequence: 10 givenname: Qinghui surname: Ai fullname: Ai, Qinghui |
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| Cites_doi | 10.1016/j.tem.2017.11.009 10.1194/jlr.M600299-JLR200 10.1016/j.cbpc.2005.01.012 10.1002/hep.21752 10.1016/j.bbalip.2019.158530 10.1194/jlr.M300013-JLR200 10.1016/j.cmet.2012.03.007 10.1038/nri3495 10.1016/j.aninu.2017.12.004 10.1007/s11010-009-0142-1 10.1093/jn/nxz135 10.1074/jbc.274.52.36827 10.1039/D0FO00804D 10.1016/j.fsi.2020.04.052 10.1016/j.fsi.2019.01.055 10.1152/ajpendo.00644.2005 10.1016/j.foodres.2020.109117 10.2337/db13-1622 10.1186/1471-230X-9-53 10.1128/IAI.01412-06 10.1111/1750-3841.15419 10.1016/j.freeradbiomed.2021.06.001 10.1097/MIB.0000000000000660 10.1016/j.ceb.2019.12.001 10.1074/jbc.M704408200 10.1016/S0898-6568(04)00028-2 10.1016/j.cmet.2007.01.002 10.1017/S0007114510000541 10.1038/s41586-021-03692-z 10.1152/ajpendo.90525.2008 10.3389/fimmu.2021.738143 10.1155/2017/4829180 10.1136/gut.2004.052316 10.1074/jbc.M010286200 10.1016/j.bbamem.2017.04.006 10.3892/ijmm.2014.1942 10.1194/jlr.M087056 10.1074/jbc.M109.031336 10.1038/s41569-019-0169-2 10.1074/jbc.M112.434183 10.1016/j.immuni.2021.07.004 10.1371/journal.pone.0129937 10.1016/j.fsi.2019.03.060 10.5402/2012/790452 10.1007/s12192-018-0936-8 10.1007/s00109-017-1534-4 10.1017/S0007114518001101 10.1038/nature05485 10.1016/j.fsi.2020.07.056 |
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| Copyright | Copyright © 2022 Fang, Liu, Chen, Xu, Liu, Cao, Hao, Zhang, Mai and Ai 2022 Fang, Liu, Chen, Xu, Liu, Cao, Hao, Zhang, Mai and Ai |
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| Notes | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 Edited by: Jiong Chen, Ningbo University, China This article was submitted to Comparative Immunology, a section of the journal Frontiers in Immunology Reviewed by: Yao Zheng, Chinese Academy of Fishery Sciences, China; Jilin Xu, Ningbo University, China |
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| References | Yu (B15) 2020; 102 Bäck (B37) 2019; 16 Ghezzal (B3) 2020; 1865 Poureslami (B28) 2010; 104 Patel (B43) 2017; 2017 Palomer (B25) 2018; 29 Fu (B29) 2012; 15 Huang (B2) 2021; 54 Kennelly (B5) 2018; 59 Ou (B48) 2020; 85 Field (B4) 2003; 44 Gwiazda (B34) 2009; 296 Treede (B6) 2009; 9 Olson (B42) 2007; 75 Song (B18) 2017; 95 Pluske (B1) 2018; 4 Zahran (B16) 2020; 106 Listenberger (B36) 2001; 276 Tasseva (B46) 2013; 288 Zhou (B9) 2018; 120 Rosqvist (B27) 2014; 63 van der Veen (B11) 2017; 1859 Yan (B20) 2015; 10 Jijon (B41) 2004; 16 Leonardi (B47) 2009; 284 Joshi-Barve (B23) 2007; 46 Stremmel (B8) 2005; 54 Tian (B49) 2020; 11 Wei (B33) 2009; 331 Bogdanov (B44) 1999; 274 Treede (B7) 2007; 282 Mizushima (B45) 2020; 63 Fu (B50) 2021; 595 Zhang (B10) 2020 Fang (B17) 2021; 12 Fang (B21) 2021; 172 Wu (B24) 2014; 34 You (B14) 2019; 89 Borradaile (B31) 2006; 47 Hotamisligil (B13) 2006; 444 Vandesompele (B22) 2002; 3 Ye (B39) 2020; 132 Wei (B30) 2006; 291 Holland (B35) 2007; 5 Oxley (B26) 2005; 141 Cao (B38) 2016; 22 Ling (B12) 2019; 149 Yang (B32) 2018; 23 Li (B19) 2019; 87 Arthur (B40) 2013; 13 |
| References_xml | – volume: 29 year: 2018 ident: B25 article-title: Palmitic and oleic acid: The yin and yang of fatty acids in type 2 diabetes mellitus publication-title: Trends Endocrin Met doi: 10.1016/j.tem.2017.11.009 contributor: fullname: Palomer – volume: 47 year: 2006 ident: B31 article-title: Disruption of endoplasmic reticulum structure and integrity in lipotoxic cell death publication-title: J Lipid Res doi: 10.1194/jlr.M600299-JLR200 contributor: fullname: Borradaile – volume: 141 start-page: 77 year: 2005 ident: B26 article-title: Enzyme activities of intestinal triacylglycerol and phosphatidylcholine biosynthesis in Atlantic salmon (Salmo salar l.) publication-title: Comp Biochem Phys B doi: 10.1016/j.cbpc.2005.01.012 contributor: fullname: Oxley – volume: 46 year: 2007 ident: B23 article-title: Palmitic acid induces production of proinflammatory cytokine interleukin-8 from hepatocytes publication-title: Hepatology doi: 10.1002/hep.21752 contributor: fullname: Joshi-Barve – volume: 1865 start-page: 158530 year: 2020 ident: B3 article-title: Palmitic acid damages gut epithelium integrity and initiates inflammatory cytokine production publication-title: BBA-Mol Cell Biol L doi: 10.1016/j.bbalip.2019.158530 contributor: fullname: Ghezzal – volume: 44 year: 2003 ident: B4 article-title: Fatty acid flux suppresses fatty acid synthesis in hamster intestine independently of SREBP-1 expression publication-title: J Lipid Res doi: 10.1194/jlr.M300013-JLR200 contributor: fullname: Field – volume: 15 year: 2012 ident: B29 article-title: The role of endoplasmic reticulum in hepatic lipid homeostasis and stress signaling publication-title: Cell Metab doi: 10.1016/j.cmet.2012.03.007 contributor: fullname: Fu – volume: 13 year: 2013 ident: B40 article-title: Mitogen-activated protein kinases in innate immunity publication-title: Nat Rev Immunol doi: 10.1038/nri3495 contributor: fullname: Arthur – volume: 4 year: 2018 ident: B1 article-title: Gastrointestinal tract (gut) health in the young pig publication-title: Anim Nutr doi: 10.1016/j.aninu.2017.12.004 contributor: fullname: Pluske – volume: 331 start-page: 31 year: 2009 ident: B33 article-title: Reduced endoplasmic reticulum luminal calcium links saturated fatty acid-mediated endoplasmic reticulum stress and cell death in liver cells publication-title: Mol Cell Biochem doi: 10.1007/s11010-009-0142-1 contributor: fullname: Wei – volume: 149 year: 2019 ident: B12 article-title: Endoplasmic reticulum stress-mediated autophagy and apoptosis alleviate dietary fat-induced triglyceride accumulation in the intestine and in isolated intestinal epithelial cells of yellow catfish publication-title: J Nutr doi: 10.1093/jn/nxz135 contributor: fullname: Ling – volume: 274 year: 1999 ident: B44 article-title: Lipid-assisted protein folding publication-title: J Biol Chem doi: 10.1074/jbc.274.52.36827 contributor: fullname: Bogdanov – volume: 11 year: 2020 ident: B49 article-title: The exogenous natural phospholipids, EPA-PC and EPA-PE, contribute to ameliorate inflammation and promote macrophage polarization publication-title: Food Funct doi: 10.1039/D0FO00804D contributor: fullname: Tian – volume: 102 year: 2020 ident: B15 article-title: Berberine improved intestinal barrier function by modulating the intestinal microbiota in blunt snout bream (Megalobrama amblycephala) under dietary high-fat and high-carbohydrate stress publication-title: Fish Shellfish Immunol doi: 10.1016/j.fsi.2020.04.052 contributor: fullname: Yu – volume: 87 year: 2019 ident: B19 article-title: High percentage of dietary palm oil suppressed growth and antioxidant capacity and induced the inflammation by activation of TLR-NF-κB signaling pathway in large yellow croaker (Larimichthys crocea) publication-title: Fish Shellfish Immunol doi: 10.1016/j.fsi.2019.01.055 contributor: fullname: Li – volume: 291 year: 2006 ident: B30 article-title: Saturated fatty acids induce endoplasmic reticulum stress and apoptosis independently of ceramide in liver cells publication-title: Am J Physiol Endoc M doi: 10.1152/ajpendo.00644.2005 contributor: fullname: Wei – volume: 132 start-page: 109117 year: 2020 ident: B39 article-title: Different dietary lipid consumption affects the serum lipid profiles, colonic short chain fatty acid composition and the gut health of sprague dawley rats publication-title: Food Res Int doi: 10.1016/j.foodres.2020.109117 contributor: fullname: Ye – volume: 63 year: 2014 ident: B27 article-title: Overfeeding polyunsaturated and saturated fat causes distinct effects on liver and visceral fat accumulation in humans publication-title: Diabetes doi: 10.2337/db13-1622 contributor: fullname: Rosqvist – volume: 9 start-page: 53 year: 2009 ident: B6 article-title: TNF-alpha-induced up-regulation of pro-inflammatory cytokines is reduced by phosphatidylcholine in intestinal epithelial cells publication-title: BMC Gastroenterol doi: 10.1186/1471-230X-9-53 contributor: fullname: Treede – volume: 75 year: 2007 ident: B42 article-title: p38 mitogen-activated protein kinase controls NF-kappaB transcriptional activation and tumor necrosis factor alpha production through RelA phosphorylation mediated by mitogen- and stress-activated protein kinase 1 in response to borrelia burgdorferi antigens publication-title: Infect Immun doi: 10.1128/IAI.01412-06 contributor: fullname: Olson – volume: 85 year: 2020 ident: B48 article-title: Lycopene protects neuroblastoma cells against oxidative damage via depression of ER stress publication-title: J Food Sci doi: 10.1111/1750-3841.15419 contributor: fullname: Ou – volume: 172 year: 2021 ident: B21 article-title: Lipid overload impairs hepatic VLDL secretion via oxidative stress-mediated PKCδ-HNF4α-MTP pathway in large yellow croaker (Larimichthys crocea) publication-title: Free Radical Biol Med doi: 10.1016/j.freeradbiomed.2021.06.001 contributor: fullname: Fang – volume: 22 year: 2016 ident: B38 article-title: Epithelial ER stress in crohn's disease and ulcerative colitis publication-title: Inflammation Bowel Dis doi: 10.1097/MIB.0000000000000660 contributor: fullname: Cao – volume: 63 start-page: 1 year: 2020 ident: B45 article-title: The ATG conjugation systems in autophagy publication-title: Curr Opin Cell Biol doi: 10.1016/j.ceb.2019.12.001 contributor: fullname: Mizushima – volume: 282 year: 2007 ident: B7 article-title: Anti-inflammatory effects of phosphatidylcholine publication-title: J Biol Chem doi: 10.1074/jbc.M704408200 contributor: fullname: Treede – volume: 16 year: 2004 ident: B41 article-title: NF-kappaB inducing kinase activates NF-kappaB transcriptional activity independently of IkappaB kinase gamma through a p38 MAPK-dependent RelA phosphorylation pathway publication-title: Cell Signal doi: 10.1016/S0898-6568(04)00028-2 contributor: fullname: Jijon – volume: 5 year: 2007 ident: B35 article-title: Inhibition of ceramide synthesis ameliorates glucocorticoid-, saturated-fat-, and obesity-induced insulin resistance publication-title: Cell Metab doi: 10.1016/j.cmet.2007.01.002 contributor: fullname: Holland – volume: 104 year: 2010 ident: B28 article-title: Effect of diet, sex and age on fatty acid metabolism in broiler chickens: SFA and MUFA publication-title: Brit J Nutr doi: 10.1017/S0007114510000541 contributor: fullname: Poureslami – volume: 595 year: 2021 ident: B50 article-title: Metabolic control of T-FH cells and humoral immunity by phosphatidylethanolamine publication-title: Nature doi: 10.1038/s41586-021-03692-z contributor: fullname: Fu – volume: 296 year: 2009 ident: B34 article-title: Effects of palmitate on ER and cytosolic Ca2+ homeostasis in beta-cells publication-title: Am J Physiol Endoc M doi: 10.1152/ajpendo.90525.2008 contributor: fullname: Gwiazda – volume: 12 year: 2021 ident: B17 article-title: Endoplasmic reticulum stress disturbs lipid homeostasis and augments inflammation in the intestine and isolated intestinal cells of Large yellow croaker (Larimichthys crocea) publication-title: Front Immunol doi: 10.3389/fimmu.2021.738143 contributor: fullname: Fang – volume: 2017 start-page: 4829180 year: 2017 ident: B43 article-title: Ethanolamine and phosphatidylethanolamine: Partners in health and disease publication-title: Oxid Med Cell Longev doi: 10.1155/2017/4829180 contributor: fullname: Patel – volume: 54 year: 2005 ident: B8 article-title: Retarded release phosphatidylcholine benefits patients with chronic active ulcerative colitis publication-title: Gut doi: 10.1136/gut.2004.052316 contributor: fullname: Stremmel – volume: 276 year: 2001 ident: B36 article-title: Palmitate-induced apoptosis can occur through a ceramide-independent pathway publication-title: J Biol Chem doi: 10.1074/jbc.M010286200 contributor: fullname: Listenberger – volume: 1859 year: 2017 ident: B11 article-title: The critical role of phosphatidylcholine and phosphatidylethanolamine metabolism in health and disease publication-title: BBA-Biomembranes doi: 10.1016/j.bbamem.2017.04.006 contributor: fullname: van der Veen – volume: 34 year: 2014 ident: B24 article-title: Palmitic acid exerts pro-inflammatory effects on vascular smooth muscle cells by inducing the expression of c-reactive protein, inducible nitric oxide synthase and tumor necrosis factor-α publication-title: Int J Mol Med doi: 10.3892/ijmm.2014.1942 contributor: fullname: Wu – volume: 59 year: 2018 ident: B5 article-title: Intestinal de novo phosphatidylcholine synthesis is required for dietary lipid absorption and metabolic homeostasis publication-title: J Lipid Res doi: 10.1194/jlr.M087056 contributor: fullname: Kennelly – volume: 284 year: 2009 ident: B47 article-title: Elimination of the CDP-ethanolamine pathway disrupts hepatic lipid homeostasis publication-title: J Biol Chem doi: 10.1074/jbc.M109.031336 contributor: fullname: Leonardi – volume: 16 start-page: 389 year: 2019 ident: B37 article-title: Inflammation and its resolution in atherosclerosis: mediators and therapeutic opportunities publication-title: Nat Rev Cardiol doi: 10.1038/s41569-019-0169-2 contributor: fullname: Bäck – volume: 288 year: 2013 ident: B46 article-title: Phosphatidylethanolamine deficiency in mammalian mitochondria impairs oxidative phosphorylation and alters mitochondrial morphology publication-title: J Biol Chem doi: 10.1074/jbc.M112.434183 contributor: fullname: Tasseva – volume: 54 start-page: 1728 year: 2021 ident: B2 article-title: Multiomics analyses reveal a critical role of selenium in controlling T cell differentiation in crohn's disease publication-title: Immunity doi: 10.1016/j.immuni.2021.07.004 contributor: fullname: Huang – volume: 10 year: 2015 ident: B20 article-title: Dietary lipid levels influence lipid deposition in the liver of Large yellow croaker (Larimichthys crocea) by regulating lipoprotein receptors, fatty acid uptake and triacylglycerol synthesis and catabolism at the transcriptional level publication-title: PLoS One doi: 10.1371/journal.pone.0129937 contributor: fullname: Yan – volume-title: Mechanism of endoplasmic reticulum stress regulating inflammatory response and lipid metabolism in large yellow croaker (Larimichthys crocea) year: 2020 ident: B10 contributor: fullname: Zhang – volume: 89 year: 2019 ident: B14 article-title: Effects of dietary lipid sources on the intestinal microbiome and health of golden pompano (Trachinotus ovatus) publication-title: Fish Shellfish Immunol doi: 10.1016/j.fsi.2019.03.060 contributor: fullname: You – volume: 3 start-page: Research0034 year: 2002 ident: B22 article-title: Accurate normalization of real-time quantitative RT-PCR data by geometric averaging of multiple internal control genes publication-title: Genome Biol doi: 10.5402/2012/790452 contributor: fullname: Vandesompele – volume: 23 year: 2018 ident: B32 article-title: Palmitic acid induces human osteoblast-like saos-2 cell apoptosis via endoplasmic reticulum stress and autophagy publication-title: Cell Stress Chaperon doi: 10.1007/s12192-018-0936-8 contributor: fullname: Yang – volume: 95 year: 2017 ident: B18 article-title: CREBH mediates metabolic inflammation to hepatic VLDL overproduction and hyperlipoproteinemia publication-title: J Mol Med doi: 10.1007/s00109-017-1534-4 contributor: fullname: Song – volume: 120 year: 2018 ident: B9 article-title: Ethanolamine enhances intestinal functions by altering gut microbiome and mucosal anti-stress capacity in weaned rats publication-title: Brit J Nutr doi: 10.1017/S0007114518001101 contributor: fullname: Zhou – volume: 444 year: 2006 ident: B13 article-title: Inflammation and metabolic disorders publication-title: Nature doi: 10.1038/nature05485 contributor: fullname: Hotamisligil – volume: 106 year: 2020 ident: B16 article-title: Withania somnifera dietary supplementation improves lipid profile, intestinal histomorphology in healthy Nile tilapia (Oreochromis niloticus), and modulates cytokines response to streptococcus infection publication-title: Fish Shellfish Immunol doi: 10.1016/j.fsi.2020.07.056 contributor: fullname: Zahran |
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| Snippet | In the 21
st
century, intestinal homeostatic imbalance has emerged as a growing health challenge worldwide. Accumulating evidence reveals that excessive intake... In the 21st century, intestinal homeostatic imbalance has emerged as a growing health challenge worldwide. Accumulating evidence reveals that excessive intake... |
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| SubjectTerms | ER stress Immunology inflammatory response intestinal homeostasis lipid metabolism palmitic acid phosphatidylethanolamine |
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| Title | Palmitic acid induces intestinal lipid metabolism disorder, endoplasmic reticulum stress and inflammation by affecting phosphatidylethanolamine content in large yellow croaker Larimichthys crocea |
| URI | https://search.proquest.com/docview/2709912453 https://pubmed.ncbi.nlm.nih.gov/PMC9437641 https://doaj.org/article/dea33b66ba424d69b6108a2a63b51ac1 |
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