Identification of solamargine as a cisplatin sensitizer through phenotypical screening in cisplatin-resistant NSCLC organoids

Although Cisplatin (DDP) is a widely used first-line chemotherapy medication, DDP resistance is one of the main causes of treatment failure in advanced lung cancer. Therefore, it is urgent to identify DDP sensitizers and investigate the underlying molecular mechanisms. Here we utilized DDP-resistant...

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Bibliographic Details

Published in:	Frontiers in pharmacology Vol. 13; p. 802168
Main Authors:	Han, Yi, Shi, Jianquan, Xu, Ziwei, Zhang, Yushan, Cao, Xiaoqing, Yu, Jianhua, Li, Jie, Xu, Shaofa
Format:	Journal Article
Language:	English
Published:	Frontiers Media S.A 10-08-2022
Subjects:	cisplatin resistance hedgehog lung cancer patient-derived organoids Pharmacology solamargine
Online Access:	Get full text
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