A low polymorphic mouse H-2 class I gene from the Tla complex is expressed in a broad variety of cell types

• Published in: The Journal of experimental medicine Vol. 166; no. 2; pp. 341 - 361
• Main Authors: TRANSY, C, NASH, S. R, DAVID-WATINE, B, COCHET, M, HUNT, S. W. III, HOOD, L. E, KOURILSKY, P
• Format: Journal Article
• Language: English
• Published: New York, NY Rockefeller University Press 01-08-1987; The Rockefeller University Press
• Subjects: Animals; Applied sciences; Base Sequence; Chromosome Mapping; DNA Restriction Enzymes; Exact sciences and technology; Genes, MHC Class II; H-2 Antigens - genetics; Mice; Mice, Inbred BALB C - genetics; Other techniques and industries; Polymorphism, Genetic; RNA, Messenger - analysis; Tissue Distribution
• ISSN: 0022-1007; 1540-9538
• DOI: 10.1084/jem.166.2.341

We have previously described the isolation of pH-2d-37, a cDNA clone that encodes a so far unknown, poorly polymorphic, class I surface molecule. We report here the isolation of the corresponding gene, its nucleotide sequence, and its localization in the Tla region of the murine MHC. Using a RNase mapping assay, we have confirmed that the second domain coding region of the 37 gene displays very limited polymorphism, and that the gene is transcribed in a broad variety of cell types, in contrast to the genes encoding the known Qa and TL antigens. Possible functions are discussed.