THE NEXT GENERATION OF LIPOSOME DELIVERY SYSTEMS: RECENT EXPERIENCE WITH TUMOR-TARGETED, STERICALLY-STABILIZED IMMUNOLIPOSOMES AND ACTIVE-LOADING GRADIENTS

ABSTRACT Three topics are discussed. Enhanced anti-tumor efficacy of targeted doxorubicin-containing sterically-stabilized liposomes using an anti-β1 integrin Fab' ligand. Use of tumor targeting with an internalizing ligand to improve the efficacy of a non-leaky cisplatin-containing sterically-...

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Bibliographic Details
Published in:	Journal of liposome research Vol. 12; no. 1-2; pp. 1 - 3
Main Authors:	Abra, R. M., Bankert, R. B., Chen, F., Egilmez, N. K., Huang, K., Saville, R., Slater, J. L., Sugano, M., Yokota, S. J.
Format:	Journal Article
Language:	English
Published:	England Informa UK Ltd 01-01-2002 Taylor & Francis
Subjects:	Ammonium Sulfate - pharmacology Anticoagulants - administration & dosage Antineoplastic Agents - administration & dosage Antineoplastic Agents, Phytogenic - administration & dosage Camptothecin - administration & dosage Cisplatin - administration & dosage Dextrans - pharmacology Doxorubicin - administration & dosage Drug Delivery Systems Ligands Lipid Bilayers - metabolism Liposomes - metabolism
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Summary:	ABSTRACT Three topics are discussed. Enhanced anti-tumor efficacy of targeted doxorubicin-containing sterically-stabilized liposomes using an anti-β1 integrin Fab' ligand. Use of tumor targeting with an internalizing ligand to improve the efficacy of a non-leaky cisplatin-containing sterically-stabilized liposome formulation. Formulation variables (remote-loading with dextran ammonium sulfate, rigid lipid bilayer) used to optimize in vivo performance of a liposomal camptothecin analog.
Bibliography:	ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-1 content type line 23 ObjectType-Feature-3 ObjectType-Review-1
ISSN:	0898-2104 1532-2394
DOI:	10.1081/LPR-120004770