Flow blockage disrupts cilia-driven fluid transport in the epileptic brain

A carpet of ependymal motile cilia lines the brain ventricular system, forming a network of flow channels and barriers that pattern cerebrospinal fluid (CSF) flow at the surface. This CSF transport system is evolutionary conserved, but its physiological function remains unknown. Here we investigated...

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Bibliographic Details
Published in:	Acta neuropathologica Vol. 144; no. 4; pp. 691 - 706
Main Authors:	Faubel, Regina J., Santos Canellas, Veronica S., Gaesser, Jenna, Beluk, Nancy H., Feinstein, Tim N., Wang, Yong, Yankova, Maya, Karunakaran, Kalyani B., King, Stephen M., Ganapathiraju, Madhavi K., Lo, Cecilia W.
Format:	Journal Article
Language:	English
Published:	Berlin/Heidelberg Springer Berlin Heidelberg 01-10-2022 Springer Springer Nature B.V
Subjects:	Age Anesthesia Animals Brain Cerebrospinal fluid Cilia Cilia - genetics Convulsions & seizures Epilepsy Epileptic Syndromes Etiology Evolutionary conservation Fluid flow Fluorescent indicators Genetic aspects Humans Medical research Medicine Medicine & Public Health Medicine, Experimental Mice Mice, Knockout Neurodevelopmental disorders Neurosciences Original Paper Pathology Physiology Protein Serine-Threonine Kinases - genetics Seizures Seizures (Medicine) Spasms, Infantile Structure-function relationships Therapeutic targets Ventricle Ventricles (cerebral) Homeostasis Seizure Cerebrospinal fluid Transport Epilepsy Cilia
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