Granular Cell Tumour of the Larynx

• Published in: Head & neck pathology (Totowa, N.J.) Vol. 10; no. 4; pp. 538 - 540
• Main Authors: Sproat, Rhona, Wong, Gentle, Rubin, John
• Format: Journal Article
• Language: English
• Published: New York Springer US 01-12-2016
• Subjects: Dentistry; Female; Granular Cell Tumor - pathology; Humans; Laryngeal Neoplasms - pathology; Medicine; Medicine & Public Health; Middle Aged; Oral and Maxillofacial Surgery; Otorhinolaryngology; Pathology; Sine qua non Clinicopathologic Correlation; Granular cell tumour; Larynx; Histopathology; Surgery
• ISSN: 1936-055X; 1936-0568
• DOI: 10.1007/s12105-016-0736-3

A 55-year-old lady with a 6 month history of hoarse voice presented to our ENT department. Endoscopic examination displayed a white left arytenoid lesion. Biopsy of this lesion displayed a nodule covered with non-keratinizing stratified squamous epithelium, with a central core of polygonal cells, positive for S-100 staining. This confirmed a granular cell tumour. CO
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laser was utilised to excise this benign tumour. Granular cell tumours of the head and neck are common, but are infrequently found in the larynx. This case report highlights the importance for the otolaryngologist to be aware of this differential diagnosis, particularly as histologically they may be confused with squamous cell carcinoma.