Compression Strength and Porosity of Single-Antibiotic Cement Vacuum-Mixed With Vancomycin

• Published in: The Journal of arthroplasty Vol. 25; no. 6; pp. 990 - 997
• Main Authors: Brock, Hugh S., MD, Moodie, Patrick G., MS, Hendricks, Kelly J., MD, McIff, Terence E., PhD
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01-09-2010
• Subjects: antibiotics; Arthroplasty, Replacement; Biomedical materials; Bone cement; Bone Cements; Cements; compression strength; Compressive Strength; Fracture surfaces; Gentamicins; Humans; Methylmethacrylate; Microscopy, Electron, Scanning; Orthopedics; Polymethyl Methacrylate; Porosity; Prosthesis-Related Infections - prevention & control; Roughness; Surface Properties; surface roughness; Surgical implants; Tobramycin; Vacuum; vacuum-mixing; Vancomycin; Bone cement; vacuum-mixing; compression strength; antibiotics; porosity; surface roughness
• ISSN: 0883-5403; 1532-8406
• DOI: 10.1016/j.arth.2009.06.027

Abstract We evaluated the ultimate compression strength (UCS), porosity, and fracture surface roughness of 2 commercially available single-antibiotic bone cements vacuum-mixed with additional amounts of vancomycin (2, 4, 6, and 8 g). At least 8 g could be added to Palacos R + 0.5 g gentamicin (UCS = 75.04 ± 6.64 MPa) and no more than 6 g to Simplex P + 1 g tobramycin (UCS = 78.93 ± 4.98 MPa) to maintain a UCS above the International Organization for Standardization minimum standard (70 MPa). Increasing vancomycin concentration correlated with a decrease in porosity but showed a trend towards greater fracture surface roughness.