Treatment of Autoimmune Bullous Diseases During Pregnancy and Lactation: A Review Focusing on Pemphigus and Pemphigoid Gestationis

Treatment of Autoimmune Bullous Diseases During Pregnancy and Lactation: A Review Focusing on Pemphigus and Pemphigoid Gestationis

Pregnancy may induce the onset or exacerbation of autoimmune bullous diseases such as pemphigus or pemphigoid gestationis. A shift toward T helper (Th) 2 immune response and the influence of hormonal changes have been evoked as possible triggering factors. Therapeutic management of this setting of p...

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Published in:Frontiers in pharmacology Vol. 11; p. 583354
Main Authors: Genovese, Giovanni, Derlino, Federica, Berti, Emilio, Marzano, Angelo Valerio
Format: Journal Article
Language:English
Published: Frontiers Media S.A 02-10-2020
Subjects:
autoimmune bullous diseases
lactation
management
pemphigus
Pharmacology
pregnancy
treatment
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Abstract Pregnancy may induce the onset or exacerbation of autoimmune bullous diseases such as pemphigus or pemphigoid gestationis. A shift toward T helper (Th) 2 immune response and the influence of hormonal changes have been evoked as possible triggering factors. Therapeutic management of this setting of patients may represent a challenge, mainly due to safety concerns of some immunosuppressive drugs during pregnancy and lactation. In this narrative review, we provided a comprehensive overview of the therapeutic management of autoimmune bullous diseases in pregnant and breastfeeding women, focusing on pemphigus and pemphigoid gestationis.
AbstractList Pregnancy may induce the onset or exacerbation of autoimmune bullous diseases such as pemphigus or pemphigoid gestationis. A shift toward T helper (Th) 2 immune response and the influence of hormonal changes have been evoked as possible triggering factors. Therapeutic management of this setting of patients may represent a challenge, mainly due to safety concerns of some immunosuppressive drugs during pregnancy and lactation. In this narrative review, we provided a comprehensive overview of the therapeutic management of autoimmune bullous diseases in pregnant and breastfeeding women, focusing on pemphigus and pemphigoid gestationis.
Author Berti, Emilio
Genovese, Giovanni
Marzano, Angelo Valerio
Derlino, Federica
AuthorAffiliation 1 Dermatology Unit, Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico , Milan , Italy
2 Department of Pathophysiology and Transplantation, Università degli Studi di Milano , Milan , Italy
3 Dermatology Unit, ASST Santi Paolo e Carlo , Milan , Italy
AuthorAffiliation_xml – name: 3 Dermatology Unit, ASST Santi Paolo e Carlo , Milan , Italy
– name: 2 Department of Pathophysiology and Transplantation, Università degli Studi di Milano , Milan , Italy
– name: 1 Dermatology Unit, Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico , Milan , Italy
Author_xml – sequence: 1
  givenname: Giovanni
  surname: Genovese
  fullname: Genovese, Giovanni
– sequence: 2
  givenname: Federica
  surname: Derlino
  fullname: Derlino, Federica
– sequence: 3
  givenname: Emilio
  surname: Berti
  fullname: Berti, Emilio
– sequence: 4
  givenname: Angelo Valerio
  surname: Marzano
  fullname: Marzano, Angelo Valerio
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Reviewed by: Aurora Parodi, University of Genoa, Italy; Gabriele Simonini, University of Florence, Italy
This article was submitted to Obstetric and Pediatric Pharmacology, a section of the journal Frontiers in Pharmacology
Edited by: Cecilia Beatrice Chighizola, Istituto Auxologico Italiano (IRCCS), Italy
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Snippet Pregnancy may induce the onset or exacerbation of autoimmune bullous diseases such as pemphigus or pemphigoid gestationis. A shift toward T helper (Th) 2...
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SubjectTerms autoimmune bullous diseases
lactation
management
pemphigus
Pharmacology
pregnancy
treatment
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Title Treatment of Autoimmune Bullous Diseases During Pregnancy and Lactation: A Review Focusing on Pemphigus and Pemphigoid Gestationis
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